Serotonergic fibers distribution in the midline and intralaminar thalamic nuclei in the rock cavy (Kerodon rupestris)

被引：3

作者：

de Medeiros Silva, Alane ^{[1
]}

Dantas de Santana, Melquisedec Abiare ^{[1
]}

Araujo de Gois Morais, Paulo Leonardo ^{[1
]}

de Sousa, Twyla Barros ^{[1
]}

Galvao Januario Engelberth, Rovena Clara ^{[2
]}

de Souza Lucena, Eudes Euler ^{[2
]}

das Chagas Campelo, Clarissa Loureiro ^{[3
]}

Cavalcante, Jeferson Sousa ^{[2
]}

Cavalcante, Judney Cley ^{[1
]}

Maris de Oliveira Costa, Miriam Stela ^{[1
]}

do Nascimento, Expedito Silva, Jr. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Norte, Biosci Ctr, La Neuroanat, Dept Morphol, BR-59072970 Natal, RN, Brazil

[2] Univ Fed Rio Grande do Norte, Biosci Ctr, La Neuroanat, Dept Physiol, BR-59072970 Natal, RN, Brazil

[3] Univ Fed Rio Grande do Norte, Biosci Ctr, Memory Studies Lab, Dept Physiol, BR-59072970 Natal, RN, Brazil

来源：

BRAIN RESEARCH | 2014年 / 1586卷

关键词：

Serotonergic system; Midline/intralaminar nuclei; Thalamus; Rock cavy; Optical density; Fiber morphology; LATERAL GENICULATE-NUCLEUS; CENTRAL-NERVOUS-SYSTEM; DORSAL RAPHE NUCLEUS; MEDIAL PREFRONTAL CORTEX; IN-SITU HYBRIDIZATION; ZEALAND WHITE-RABBIT; ASCENDING PROJECTIONS; BRAIN-STEM; CELL-BODIES; SEROTONINERGIC INNERVATION;

D O I：

10.1016/j.brainres.2014.08.047

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The thalamic midline/intralaminar complex is part of the higher-order thalamus, which receives little sensory input, and instead forms extensive cortico-thalamo-cortical pathways. The midline thalamic nuclei connect with the medial prefrontal cortex and the medial temporal lobe. On the other hand, the intralaminar nuclei connect with the fronto-parietal cortex. Taking into account this connectivity pattern, it is not surprising that the midline/intralaminar complex has been implicated in a broad variety of cognitive functions, including memory process, attention and orientation, and also reward-based behavior. Serotonin (5-HT) is a neurotransmitter that exerts different post-synaptic roles. Serotonergic neurons are almost entirely restricted to the raphe nuclei and the 5-HT fibers are distributed widely throughout the brain, including the midline/intralaminar complex. The present study comprises a detailed description of the morphologic features and semiquantitative analysis of 5-HT fibers distribution in the midline/intralaminar complex in the rock cavy, a typical rodent of the Northeast region of Brazil, which has been used by our group as an anatomical model to expand the comprehension about phylogeny on the nervous system. The 5-HT fibers in the midline/intralaminar nuclei of the rock cavy were classified into three distinct categories: (1) beaded fibers, which are relatively fine and endowed with large varicosities; (2) fine fibers, with thin axons and small varicosities uniformly distributed in whole axon; and (3) stem axons, showing thick non-varicose axons. Moreover, the density-of 5-HT fibers is variable among the analyzed nuclei. On the basis of this diversity of the morphological fibers and the differential profile of optical density among the midline/intralaminar nuclei of the rock cavy, we conclude that the serotonergic system uses a diverse morphologic apparatus to exert a large functional repertory in the midline/intralaminar thalamic nuclei. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：99 / 108

页数：10

共 42 条

[41] Damage to the dorsomedial thalamic nucleus, central lateral intralaminar thalamic nucleus, and midline thalamic nuclei on the right-side impair executive function and attention under conditions of high demand but not low demand
Edelstyn, N. M. J.
Mayes, A. R.
Ellis, S. J.
NEUROCASE, 2014, 20 (02) : 121 - 132
[42] THE LAMINAR DISTRIBUTION AND ULTRASTRUCTURE OF FIBERS PROJECTING FROM 3 THALAMIC NUCLEI TO THE SOMATIC SENSORY-MOTOR CORTEX OF THE OPOSSUM
DONOGHUE, JP
EBNER, FF
JOURNAL OF COMPARATIVE NEUROLOGY, 1981, 198 (03) : 389 - 420

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