Type 1 diabetes. From biomarkers to prevention

被引：2
|
作者：
Boitard, Christian [1 ]
机构：
[1] Hop Cochin, Serv Diabetol, 123 Blvd Port Royal, F-75014 Paris, France
来源：
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE | 2017年 / 201卷 / 1-3期
关键词：
DIABETES MELLITUS; TYPE I; AUTOANTIBODIES; AUTOIMMUNITY; ENVIRONMENT; IMMUNOTHERAPY; NOD MICE; ISLET AUTOANTIBODIES; RISK-FACTORS; BETA-CELLS; PROGRESSION; GENETICS; HUMANS; SYSTEM;
D O I：
10.1016/S0001-4079(19)30527-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 1 diabetes is an auto-immune disease that leads to the destruction of insulin-secreting cells by the immune system. The auto-immune response to insulin-secreting cells, from the expansion of autoreactive lymphocytes to the activation of effectors involved in the destruction of insulin-secreting cells, has been extensively defined in preclinical models of type 1 diabetes. However, underlying mechanisms initiating the autoimmune process remain ill-defined. The type I diabetes challenge is in relating immune mechanisms involved with new therapeutic strategies that will lead to disease prevention. The identification of new biomarkers is a prerequisite for progress towards preventive strategies.
引用
收藏
页码：297 / 307
页数：11
相关论文
共 50 条
  • [31] The potential use of biomarkers in the prevention of Type 2 diabetes
    Steinbrecher, Astrid
    Pischon, Tobias
    EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2013, 8 (03) : 217 - 219
  • [32] PAI-1 activity in pregnants with type 1 and type 2 diabetes.
    Bronisz, A
    Rosc, D
    Kotschy, M
    GraczykowskaKoczorowska, A
    DIABETOLOGIA, 1997, 40 : 892 - 892
  • [33] Plasma homocysteine and chronic complications in type 1 diabetes.
    Hermans, MP
    Jamart, J
    Dramais, AS
    Wallemacq, P
    Buysschaert, M
    DIABETOLOGIA, 2001, 44 : A308 - A308
  • [34] Bariatric Surgery in the Prevention of Diabetes. Experiences from the SOS Study
    Sjostrom, Lars
    OBESITY SURGERY, 2012, 22 (09) : 1317 - 1317
  • [35] Infant Formula, Autoimmune Triggers, and Type 1 Diabetes.
    Harlan, David M.
    Lee, Mary M.
    NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (20): : 1961 - 1963
  • [36] Hepatic lipase and glycemic control in type 1 diabetes.
    Sibley, SD
    Purnell, JQ
    Hirsch, IB
    Palmer, JP
    Cleary, PA
    Brunzeil, JD
    JOURNAL OF INVESTIGATIVE MEDICINE, 2000, 48 (05) : 264A - 264A
  • [37] B-cell deficiency and type 1 diabetes.
    Farid, NR
    NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (07): : 538 - 538
  • [38] Substance P delays onset of type 1 diabetes.
    Um, J.
    Jung, N.
    Choi, S.
    Son, Y.
    Park, K.
    MOLECULAR BIOLOGY OF THE CELL, 2014, 25
  • [39] Mass spectrometry and understanding the origin of type 1 diabetes.
    Gross, ML
    Unanue, E
    Suri, A
    Vidavsky, I
    van der Drift, K
    Levisetti, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : U89 - U89
  • [40] Microvascular and macrovascular risk factors in type 1 diabetes.
    Groop, PH
    Mills, V
    Rosengard-Barlund, M
    Forsblom, C
    Thomas, S
    Gnudi, L
    Viberti, G
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2002, 13 : 250A - 250A
12345