A Parylene Self-Locking Cuff Electrode for Peripheral Nerve Stimulation and Recording

The cuff electrode provides a stable interface with the peripheral nerve, which has been widely utilized in both basic research and clinical practice over the past few decades. In this paper, we present a microfabricated, parylene-based self-locking cuff electrode. The cuff diameter can be adjusted to accommodate the nerve properly during implantation. This type of cuff electrodes is easy to implant and the cuff was made of the thin, flexible, and biocompatible parylene substrate. Moreover, the integrated parylene cable and pads facilitate the connection with external circuits. Electrochemical properties of electrode sites were characterized by impedance spectroscopy and cyclic voltammetry. The average impedance magnitude and average charge delivery capacity of the Pt electrodes are 8.3 k Omega (at 1 kHz) and 2.8 mC/cm(2), respectively. Using the proposed cuff electrodes, the evoked compound action potentials of the rat sciatic nerve were successfully recorded. Electrical stimulation tests proved the feasibility of selective stimulation of tibial and peroneal fascicles within the rat sciatic nerve. This type of cuff electrodes induced only a benign foreign body reaction and did not damage the axons within the rat sciatic nerve over 11 weeks of an implantation period. [2014-0062]