Bipolar electroactive conducting polymers for wireless cell stimulation

被引：26
|
作者：
Qin, Chunyan [1 ]
Yue, Zhilian [1 ]
Chao, Yunfeng [1 ]
Forster, Robert J. [2 ]
Maolmhuaidh, Fionn O. [2 ]
Huang, Xu-Feng [3 ]
Beirne, Stephen [1 ]
Wallace, Gordon G. [1 ]
Chen, Jun [1 ]
机构：
[1] Univ Wollongong, Intelligent Polymer Res Inst, ARC Ctr Excellence Electromat Sci, Australian Inst Innovat Mat, Innovation Campus,Squires Way, North Wollongong, NSW 2519, Australia
[2] Dublin City Univ, Sch Chem Sci, Natl Ctr Sensor Res, Dublin 9, Ireland
[3] Univ Wollongong, Illawarra Hlth & Med Res Inst, Sch Med, Wollongong, NSW 2522, Australia
来源：
APPLIED MATERIALS TODAY | 2020年 / 21卷
基金：
澳大利亚研究理事会;
关键词：
Cell stimulation; Bipolar electrostimulation; Conducting polymer; Bipolar electroactive; Wireless; 3D Printing; NERVE GROWTH-FACTOR; ELECTRODE; ELECTROCHEMISTRY; POLYPYRROLE; COLLAGEN; ARRAY;
D O I：
10.1016/j.apmt.2020.100804
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Conventional organic conducting polymers (CPs)-based electrical stimulation (ES) systems have been extensively explored in modulation of cell and tissue functions for biomedical applications. Bipolar electrochemistry could offer an effective pathway to modify these ES systems into a more desirable contactless mode. In this study, we present for the first time the development of a CP-based bipolar electrostimulation (BPES) system for living cells. Polypyrrole (PPy) films with different dopants have been utilised to demonstrate reversible and recoverable bipolar electrochemical activity under a low driving DC voltage (<5.5 V). A BPES prototype enabling wireless and programmable cell stimulation has been devised using PPy co-doped with dextran sulfate (DS) and collagen (PPy-DS/collagen) as a bipolar electrode and rat pheochromocytoma cells as a model cell line. Significantly, wireless stimulation enhances cell proliferation and differentiation. The work establishes a new paradigm for the electrostimulation of living cells using CPs as the bipolar electrodes, which provides an attractive wireless approach to advance the field of medical bionics. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：9
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