Development of insulin resistance in experimental animals during long-term glucocorticoid treatment

被引：5
|
作者：
Selyatitskaya, VG [1 ]
Kuz'minova, OI [1 ]
Odintsov, SV [1 ]
机构：
[1] Russian Acad Med Sci, Lab Endocrinol, Res Ctr Clin & Expt Med, Siberian Div, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 04期
关键词：
glucocorticoids; insulin; glucose; galycogen; insulin resistance;
D O I：
10.1023/A:1016281501423
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Long-term treatment with glucocorticoids led to the development of insulin resistance in experimental animals, which was confirmed by a progressive increase in blood insulin level and decrease in the glucose/insulin index. The comparative study showed that hydrocortisone produced more pronounced and rapid changes than dexamethasone. However, we found no differences in the glucose/insulin index by the 23rd day of treatment with these hormones.
引用
收藏
页码：339 / 341
页数：3
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