Development of insulin resistance in experimental animals during long-term glucocorticoid treatment

被引：5
|
作者：
Selyatitskaya, VG [1 ]
Kuz'minova, OI [1 ]
Odintsov, SV [1 ]
机构：
[1] Russian Acad Med Sci, Lab Endocrinol, Res Ctr Clin & Expt Med, Siberian Div, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 04期
关键词：
glucocorticoids; insulin; glucose; galycogen; insulin resistance;
D O I：
10.1023/A:1016281501423
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Long-term treatment with glucocorticoids led to the development of insulin resistance in experimental animals, which was confirmed by a progressive increase in blood insulin level and decrease in the glucose/insulin index. The comparative study showed that hydrocortisone produced more pronounced and rapid changes than dexamethasone. However, we found no differences in the glucose/insulin index by the 23rd day of treatment with these hormones.
引用
收藏
页码：339 / 341
页数：3
相关论文
共 50 条
  • [21] REPAIR OF EXPERIMENTAL FRACTURES DURING LONG-TERM ANTICOAGULANT TREATMENT - AN EXPERIMENTAL STUDY ON RATS
    ROKKANEN, P
    SLATIS, P
    ACTA ORTHOPAEDICA SCANDINAVICA, 1964, 35 (01): : 21 - &
  • [22] Sublethal Ciprofloxacin Treatment Leads to Rapid Development of High-Level Ciprofloxacin Resistance during Long-Term Experimental Evolution of Pseudomonas aeruginosa
    Jorgensen, Karin Meinike
    Wassermann, Tina
    Jensen, Peter Ostrup
    Wang Hengzuang
    Molin, Soren
    Hoiby, Niels
    Ciofu, Oana
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (09) : 4215 - 4221
  • [23] Development of Peyronie's disease during long-term colchicine treatment
    Tibet Erdogru
    Mustafa F. Usta
    Mutlu Ates
    Sahin Yigit
    International Urology and Nephrology, 2003, 35 (2) : 207 - 208
  • [24] The development of individual treatment goals during long-term psychodynamic therapies
    Huber, D
    Klug, G
    Brandl, T
    von Rad, M
    PSYCHOTHERAPIE PSYCHOSOMATIK MEDIZINISCHE PSYCHOLOGIE, 1999, 49 (11) : 462 - 462
  • [25] Effects of long-term flutamide treatment during development in zebra finches
    Grisham, William
    Park, Sun Hee
    Hsia, Jennifer K.
    Kim, Caroline
    Leung, Michael C.
    Kim, Linda
    Arnold, Arthur P.
    NEUROSCIENCE LETTERS, 2007, 418 (01) : 92 - 96
  • [26] LOSS OF EFFICACY DURING LONG-TERM CIFENLINE THERAPY - DEVELOPMENT OF ANTIARRHYTHMIC RESISTANCE
    MOHIUDDIN, SM
    HEE, TT
    HUNTER, CB
    HILLEMAN, DE
    SKETCH, MH
    ANNALS OF PHARMACOTHERAPY, 1993, 27 (05) : 550 - 554
  • [27] No Resistance to Tenofovir following long-term Treatment
    Weiss, Johannes
    ZEITSCHRIFT FUR GASTROENTEROLOGIE, 2011, 49 (07): : 796 - 796
  • [28] Long-term expression of insulin in skeletal muscle does not lead to insulin resistance
    Hidalgo, A
    Mas, A
    Ferré, T
    Otaegui, PJ
    Riu, E
    Bosch, F
    GENE THERAPY, 2004, 11 : S151 - S151
  • [29] Long-term expression of insulin in skeletal muscle does not lead to insulin resistance
    Hidalgo, A
    Mas, A
    Ferre, T
    Otaegui, P
    Riu, E
    Bosch, F
    DIABETOLOGIA, 2003, 46 : A214 - A214
  • [30] LONG-TERM TREATMENT WITH DES-PHE-INSULIN
    HIRN, S
    PIETSCHMANN, H
    WIENER KLINISCHE WOCHENSCHRIFT, 1982, 94 (24) : 662 - 665
12345