Sexual Function in Men Treated for Testicular Cancer

被引:47
|
作者
Eberhard, Jakob [1 ,2 ]
Stahl, Olof [1 ,2 ]
Cohn-Cedermark, Gabriella [3 ]
Cavallin-Stahl, Eva [1 ]
Giwercman, Yvonne [4 ]
Rylander, Lars [4 ,5 ]
Eberhard-Gran, Malin [6 ]
Kvist, Ulrik [7 ,8 ]
Fugl-Meyer, Kerstin S. [7 ,8 ]
Giwercman, Aleksander [2 ,4 ]
机构
[1] Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
[2] Lund Univ, Malmo Univ Hosp, Dept Reprod Med, Malmo, Sweden
[3] Karolinska Univ Hosp, Dept Oncol Pathol, Radiumhemmet, Stockholm, Sweden
[4] Lund Univ, Dept Clin Sci, Lund, Sweden
[5] Lund Univ, Div Occupat & Environm Med, Lund, Sweden
[6] Norwegian Inst Publ Hlth, Div Mental Hlth, Oslo, Norway
[7] Karolinska Univ Hosp, Karolinska Inst, Ctr Androl & Sexual Med, Stockholm, Sweden
[8] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden
来源
JOURNAL OF SEXUAL MEDICINE | 2009年 / 6卷 / 07期
关键词
Testicular Cancer; Hypogonadism; Sexual Satisfaction; Sexual Dysfunction; Sexuality; Oncology; GERM-CELL-CANCER; EUROPEAN CONSENSUS CONFERENCE; QUALITY-OF-LIFE; GROUP EGCCCG; THERAPY; RADIOTHERAPY; FERTILITY; SURVIVORS; TESTIS; TESTOSTERONE;
D O I
10.1111/j.1743-6109.2009.01298.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Introduction. Testicular germ cell cancer (TGCC) patients may be at risk of developing sexual dysfunction after treatment. Aim. The aim of this study was to assess the prevalence of sexual dysfunctions in TGCC patients 3 to 5 years after treatment, and relate findings to biochemical hypogonadism, treatment intensity, and the expected prevalence in the Swedish male population. Methods. A questionnaire study on 129 consecutive TGCC patients 3 to 5 years post-treatment was performed. Comparators were an age-matched nationally representative group of men (N = 916) included in a study on sexual life in Sweden. Main Outcome Measures. Sexual functions (including erectile dysfunctional distress), time since last intercourse, sexual satisfaction, and experience of sexological treatment seeking were assessed using the same questions used in the epidemiological study on sexual life in Sweden. The findings in TGCC patients were correlated to biochemical signs of hypogonadism and type of oncological treatment: Surveillance, adjuvant chemotherapy, adjuvant radiotherapy, or standard doses of chemotherapy. Results. A higher proportion of TGCC patients than comparators were likely to report low sexual desire (odds ratio [OR] 6.7 [95% confidence interval {CI} 2.1-21]) as well as erectile dysfunction (OR 3.8 [95% CI 1.4-10]). No significant differences were observed regarding erectile dysfunctional distress, change of desire over time, interest in sex, premature or delayed ejaculation, time since last intercourse, need for or receiving sexual advice, or sexual satisfaction. Hypogonadism did not predict erectile dysfunction (OR 1.1 [95% CI 0.26-4.5]) or low sexual desire (OR 1.2 [95% CI 0.11-14]). Treatment modality had no obvious impact on sexual function. Conclusion. Men treated for testicular cancer had higher risk of having low sexual desire and erectile dysfunction 3 to 5 years after completion of therapy than comparators. These sexual dysfunctions were not significantly associated with treatment intensity or hypogonadism. Eberhard J, Stahl O, Cohn-Cedermark G, Cavallin-Stahl E, Giwercman Y, Rylander L, Eberhard-Gran M, Kvist U, Fugl-Meyer KS, and Giwercman A. Sexual function in men treated for testicular cancer. J Sex Med 2009;6:1979-1989.
引用
收藏
页码:1979 / 1989
页数:11
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