Synthesis of the Naturally Occurring (-)-1,3,5-Tri-O-Caffeoylquinic Acid

被引：7
|
作者：
Brummond, Kay M. [1 ]
DeForrest, Jolie E. [1 ]
机构：
[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
来源：
SYNLETT | 2009年 / 09期
基金：
美国国家卫生研究院;
关键词：
reverse transcriptase; ribonuclease H; (-)-1,3,5-tri-O-caffeoylquinic acid; (-)-quinic acid; RECENT PROGRESS; RNASE-H; DERIVATIVES; FORSKOLIN; ANALOGS;
D O I：
10.1055/s-0029-1217183
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ribonuclease H (RNase H) is an essential component to the replication of human immunodeficiency virus (HIV), and only a few inhibitors of this enzyme are known. Millenia Hope Pharmaceuticals Inc. found that (-)-1,3,5-tri-O-caffeoylquinic acid is a potent RNase H inhibitor and antiviral agent. A facile route leading to this inhibitor from commercially available (-)-quinic acid is reported within.
引用
收藏
页码：1517 / 1519
页数：3
相关论文
共 50 条
  • [31] Podospermic acid, 1,3,5-tri-O-(7,8-dihydrocaffeoyl)quinic acid from Podospermum laciniatum (Asteraceae)
    Zidorn, C
    Petersen, BO
    Udovicic, V
    Larsen, TO
    Duus, JO
    Rollinger, JM
    Ongania, KH
    Ellmerer, EP
    Stuppner, H
    TETRAHEDRON LETTERS, 2005, 46 (08) : 1291 - 1294
  • [32] Synthesis and Reactions of 1,3,5-Tri- and 1,3,5,7-Tetracarbonyl Compounds
    Langer, Peter
    SYNLETT, 2021, 32 (20) : 2036 - 2045
  • [33] 1,3,5-TRI-PARA-METHOXYBENZYLCYCLOHEXANE
    VANDERZANDEN, JM
    DEVRIES, G
    RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS-JOURNAL OF THE ROYAL NETHERLANDS CHEMICAL SOCIETY, 1948, 67 (12): : 998 - 1004
  • [34] 1,3,5-Tri-p-tolylbiuret
    Roh, SG
    Jeong, JH
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 2000, 56 : E529 - E530
  • [35] SYNTHESIS OF 1,3,5-TRI-O-ACYL-ALPHA-D-RIBOFURANOSES WITH SPECIFIC SUBSTITUENTS IN POSITION-2
    CHAVIS, C
    DUMONT, F
    IMBACH, JL
    JOURNAL OF CARBOHYDRATES-NUCLEOSIDES-NUCLEOTIDES, 1978, 5 (02): : 133 - 147
  • [36] BIOCHEMICAL ROLE OF NATURALLY OCCURRING POLYAMINES IN NUCLEIC ACID SYNTHESIS
    STEVENS, L
    BIOLOGICAL REVIEWS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY, 1970, 45 (01): : 1 - &
  • [37] THE UTILITY OF PODOCARPIC ACID IN THE SYNTHESIS OF NATURALLY-OCCURRING TERPENES
    BANERJEE, AK
    ACEVEDO, JC
    CANUDASGONZALEZ, N
    BULLETIN DES SOCIETES CHIMIQUES BELGES, 1990, 99 (01): : 9 - 28
  • [38] THE SYNTHESIS OF 3 NATURALLY-OCCURRING POLYACETYLENIC ESTERS
    BELL, I
    JONES, ERH
    WHITING, MC
    CHEMISTRY & INDUSTRY, 1956, (24) : 548 - 549
  • [39] SYNTHESIS AND TOXICOLOGY OF 3 NATURALLY-OCCURRING CYANOEPITHIOALKANES
    LUTHY, J
    DANIKEN, AV
    MANTHEY, B
    ZWEIFEL, U
    SCHLATTER, C
    BENN, MH
    EXPERIENTIA, 1980, 36 (06): : 765 - 765
  • [40] SYNTHESIS AND TOXICOLOGY OF 3 NATURALLY-OCCURRING CYANOEPITHIOALKANES
    LUTHI, J
    VONDANIKEN, A
    FRIEDERICH, U
    MANTHEY, B
    ZWEIFEL, U
    SCHLATTER, C
    CHIMIA, 1981, 35 (01) : 18 - 18
12345