Synthesis of the Naturally Occurring (-)-1,3,5-Tri-O-Caffeoylquinic Acid

被引：7
|
作者：
Brummond, Kay M. [1 ]
DeForrest, Jolie E. [1 ]
机构：
[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
来源：
SYNLETT | 2009年 / 09期
基金：
美国国家卫生研究院;
关键词：
reverse transcriptase; ribonuclease H; (-)-1,3,5-tri-O-caffeoylquinic acid; (-)-quinic acid; RECENT PROGRESS; RNASE-H; DERIVATIVES; FORSKOLIN; ANALOGS;
D O I：
10.1055/s-0029-1217183
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ribonuclease H (RNase H) is an essential component to the replication of human immunodeficiency virus (HIV), and only a few inhibitors of this enzyme are known. Millenia Hope Pharmaceuticals Inc. found that (-)-1,3,5-tri-O-caffeoylquinic acid is a potent RNase H inhibitor and antiviral agent. A facile route leading to this inhibitor from commercially available (-)-quinic acid is reported within.
引用
收藏
页码：1517 / 1519
页数：3
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