Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance

被引:8
|
作者
Zhou, Meicen [1 ,2 ]
He, Shuli [3 ]
Ping, Fan [1 ]
Li, Wei [1 ]
Zhu, Lixin [4 ]
Cui, Xiangli [4 ]
Feng, Linbo [5 ]
Zhao, Xuefeng [5 ]
Zhang, Huabing [1 ]
Li, Yuxiu [1 ]
Sun, Qi [1 ]
机构
[1] Peking Union Med Coll Hosp, Minist Hlth, Key Lab Endocrinol, Dept Endocrinol, Beijing 100730, Peoples R China
[2] Beijing Jishuitan Hosp, Dept Endocrinol, Beijing 100035, Peoples R China
[3] Peking Union Med Coll Hosp, Dept Nutr, Beijing 100730, Peoples R China
[4] Nankou Community Hlth Serv Ctr, Beijing 102200, Peoples R China
[5] Nankou Railway Hosp, Beijing 102200, Peoples R China
基金
中国国家自然科学基金;
关键词
INSULIN-RESISTANCE; OBESITY; UCP2; RISK; SENSITIVITY; PROMOTER;
D O I
10.1155/2018/4636783
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To investigate the association of polymorphisms in uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor (PPAR.) with glucolipid metabolism in Chinese Han population. Methods. Five hundred eighty-nine subjects were divided into normal glucose tolerance (NGT) group (n = 198) and abnormal glucose tolerance group (n = 358). HbA1c, blood lipid profile, plasma glucose, and insulin were determined. Insulin sensitivity (HOMA-IR and Matsuda index (ISIM)) and insulin secretion indexes (HOMA-beta, early and total phase disposition index) were evaluated. Eight potential functional SNPs in UCP2 and 7 in PPAR. were selected. SNPs were genotyped on Sequenom MassARRAY platform. Results. The GG genotype of rs2920502 in PPAR. was associated with decreased risk of impaired glucose tolerance (G allele: OR: 0.818, 95% CI: 0.526-0.969, P = 0 042; GG: OR: 0.715, 95% CI: 0.527-0.97, P = 0 031). The TT genotype of rs3856806 in PPAR. was associated with increased risk of impaired glucose tolerance (T allele: OR: 1.46, 95% CI: 1.055-2.017, P = 0 022; TT: OR: 1.58, 95% CI: 1.104-2.761, P = 0 032). The GG genotype of rs2920502 in PPAR. had better blood glucose and increased insulin secretion and had lower HOMA-IR than GC/CC genotypes. Conclusion. It probably could prevent insulin resistance in early stage by classifying the genotype of rs649446 and rs7109266 in UCP2. The GG genotype of rs2920502 in PPAR. had a decreased risk for diabetes. The TT genotype of rs3856806 in PPAR. had an increased risk for diabetes.
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页数:16
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