The interplay between histone acetyltransferases (HATs) and histone deacetylases (HDACs) is key to the dynamics of chromatin structure and function. A recent report of genome-wide, microarray maps of histone acetylation has uncovered the intragenic targets for six different yeast HDACs and has led to the discovery of new heterochromatin-like domains.
机构:
Royal Ctr Def Med Res & Acad, ICT Ctr, Med Directorate, Birmingham B15 2SQ, W Midlands, EnglandRoyal Ctr Def Med Res & Acad, ICT Ctr, Med Directorate, Birmingham B15 2SQ, W Midlands, England