Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates

被引：9
|
作者：
Luo, Xiaojun [1 ]
Liu, Qiang [2 ]
Zhu, Hongxia [1 ]
Chen, Huoji [2 ]
机构：
[1] Southern Med Univ, Integrated Hosp Tradit Chinese Med, Shiliugang Rd 13th, Guangzhou 510315, Guangdong, Peoples R China
[2] Southern Med Univ, Sch Tradit Chinese Med, 1023 South Shatai Rd, Guangzhou 510515, Guangdong, Peoples R China
来源：
ROYAL SOCIETY OPEN SCIENCE | 2018年 / 5卷 / 05期
关键词：
copper catalysis; sulfenylation; indoles; sodium sulfinates; ELECTRON-RICH ARENES; METAL-FREE; EFFICIENT SULFENYLATION; ARYL; SYSTEM; FUNCTIONALIZATION; 3-SULFENYLATION; THIOLATION; GENERATION; THIOETHERS;
D O I：
10.1098/rsos.180170
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A copper-catalysed sulfenylation of indoles with sodium sulfinates that affords 3-sulfenylindoles in good-to-excellent yields in N,N-dimethyl formamide (DMF) is described. In the process, DMF serves not only as a solvent but also as a reductant. This transformation is easy to carry out and has mild reaction conditions and good functional group tolerance.
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页数：7
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