Phthalate exposure and human semen quality in Shanghai: A cross-sectional study

被引:0
|
作者
Zhang, Yun-Hui [1 ]
Zheng, Li-Xing [1 ]
Chen, Bing-Heng [1 ]
机构
[1] Fudan Univ, Sch Publ Hlth, Dept Environm Hlth, Shanghai 200032, Peoples R China
关键词
environmental endocrine disruptor; phthalates; reversed-phase HPLC; biological samples;
D O I
暂无
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Objective To monitor the level of phthalates in human semen samples and to analyze the relationship between plithalate levels and semen parameters. Methods Concentrations of three kinds of commonly used phthalates (di-ethyl plithalate, DEP; di-n-butyl phthalate, DBP; di-2-ethylhexyl phthalate, DEHP) were measured using reversed-phase HPLC. Semen parameters were measured by computer aided sperm analysis (CASA). Results The three phthalates were detected in most of the biological samples, With median levels of 0.30 mg/L (0.08-1.32 mg/L) in semen specimens. There was a significant positive association between liquefied time of semen and phthalate concentrations of semen. The correlation coefficient was 0.456 for DEP, 0.475 for DBP, and 0.457 for DEHP, respectively. There was no significant difference between phthalate concentrations of semen and sperm density or livability, though the correlation coefficients were negative. Conclusion These results suggest that people who reside in Shanghai are exposed to phthalates, especially to DBP and DEHR Although the level of phthalates is relatively mild, an association of phthalate levels and reduced quality of human semen has been shown in the present study.
引用
收藏
页码:205 / 209
页数:5
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