Association of IL-4 promoter polymorphisms with asthma: a meta-analysis

被引：11

作者：

Tang, L. ^{[1
]}

Lin, H. G. ^{[2
]}

Chen, B. F. ^{[2
]}

机构：

[1] Changsha Med Univ, Sch Basic Med Sci, Changsha, Hunan, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 01期

关键词：

IL-4; Promoter; Polymorphisms; Meta-analysis; Asthma; SERUM IGE LEVELS; INTERLEUKIN-4 GENE PROMOTER; CONFER SUSCEPTIBILITY; BRONCHIAL-ASTHMA; TNF-ALPHA; IL4; ATOPY; RISK; POPULATIONS; VARIANTS;

D O I：

10.4238/2014.February.28.11

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly associated with asthma; however, significant associations were found only in the European population. In addition, the TT+ CT genotype was significantly associated with asthma in adults and no significant association was found in asthma status subgroup analyses. This meta-analysis showed that IL-4 C-589T and C-33T were associated with asthma in Europeans. To further confirm correlations between polymorphisms of the IL-4 promoter with asthma susceptibility, studies involving a larger number of patients worldwide are necessary.

引用

页码：1383 / 1394

页数：12

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