Evaluation of Almitrine Infusion During Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome in Adults

被引：5

作者：

Esnault, Pierre ^{[1
,2
]}

Hraiech, Sami ^{[1
]}

Bordes, Julien ^{[2
]}

Forel, Jean-Marie ^{[1
]}

Adda, Melanie ^{[1
]}

Rambaud, Romain ^{[1
]}

Lehingue, Samuel ^{[1
]}

Roch, Antoine ^{[1
,3
]}

Papazian, Laurent ^{[1
]}

Guervilly, Christophe ^{[1
]}

机构：

[1] Aix Marseille Univ, Nord Hosp, AP HM,Resp Distress & Severe Infect, Med Intens Care Unit,URMITE,CNRS,UMR 6236, Marseille, France

[2] St Anne Mil Hosp, Intens Care Unit, Toulon, France

[3] Aix Marseille Univ, Nord Hosp, AP HM, Dept Emergency, Marseille, France

来源：

ANESTHESIA AND ANALGESIA | 2019年 / 129卷 / 02期

关键词：

HYPOXIC PULMONARY VASOCONSTRICTION; GAS-EXCHANGE; BISMESYLATE; HYPOXEMIA;

D O I：

10.1213/ANE.0000000000002786

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

This single-center case series investigated the effect of almitrine infusion on Pao(2)/fraction of inspired oxygen (Fio(2)) in 25 patients on veno-venous extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. A positive trial was defined as an increase of Pao(2)/Fio(2) ratio >= 20%. Thirty-two trials were performed. Twenty (62.5%, 95% confidence interval, 37.5%-75%) trials in 18 patients were positive, with a median Pao(2)/Fio(2) ratio increase of 35% (25%-43%). A focal acute respiratory distress syndrome and inhaled nitric oxide therapy were more frequent in patients with a positive response to almitrine. We observed no complications of almitrine use.

引用

页码：E48 / E51

页数：4

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