Evaluation of Almitrine Infusion During Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome in Adults

被引：5
|
作者：
Esnault, Pierre [1 ,2 ]
Hraiech, Sami [1 ]
Bordes, Julien [2 ]
Forel, Jean-Marie [1 ]
Adda, Melanie [1 ]
Rambaud, Romain [1 ]
Lehingue, Samuel [1 ]
Roch, Antoine [1 ,3 ]
Papazian, Laurent [1 ]
Guervilly, Christophe [1 ]
机构：
[1] Aix Marseille Univ, Nord Hosp, AP HM,Resp Distress & Severe Infect, Med Intens Care Unit,URMITE,CNRS,UMR 6236, Marseille, France
[2] St Anne Mil Hosp, Intens Care Unit, Toulon, France
[3] Aix Marseille Univ, Nord Hosp, AP HM, Dept Emergency, Marseille, France
来源：
ANESTHESIA AND ANALGESIA | 2019年 / 129卷 / 02期
关键词：
HYPOXIC PULMONARY VASOCONSTRICTION; GAS-EXCHANGE; BISMESYLATE; HYPOXEMIA;
D O I：
10.1213/ANE.0000000000002786
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
This single-center case series investigated the effect of almitrine infusion on Pao(2)/fraction of inspired oxygen (Fio(2)) in 25 patients on veno-venous extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. A positive trial was defined as an increase of Pao(2)/Fio(2) ratio >= 20%. Thirty-two trials were performed. Twenty (62.5%, 95% confidence interval, 37.5%-75%) trials in 18 patients were positive, with a median Pao(2)/Fio(2) ratio increase of 35% (25%-43%). A focal acute respiratory distress syndrome and inhaled nitric oxide therapy were more frequent in patients with a positive response to almitrine. We observed no complications of almitrine use.
引用
收藏
页码：E48 / E51
页数：4
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