The structure of the human 4F2hc-LAT1 heteromeric amino acid transporter

被引：4
|
作者：
Fotiadis, Dimitrios [1 ]
Jeckelmann, Jean-Marc
机构：
[1] Univ Bern, Inst Biochem & Mol Med, CH-3012 Bern, Switzerland
来源：
SCIENCE CHINA-LIFE SCIENCES | 2019年 / 62卷 / 06期
关键词：
D O I：
10.1007/s11427-019-9558-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
[No abstract available]
引用
收藏
页码：848 / 850
页数：3
相关论文
共 50 条
  • [11] Volta Phase Plate Cryo-EM Structure of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2
    Jeckelmann, Jean-Marc
    Fotiadis, Dimitrios
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (04):
  • [12] Characterization of substrates and inhibitors of the human heterodimeric transporter 4F2hc-LAT1 using purified protein and the scintillation proximity radioligand binding assay
    Kantipudi, Satish
    Harder, Daniel
    Fotiadis, Dimitrios
    FRONTIERS IN PHYSIOLOGY, 2023, 14
  • [13] Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and-LAT2, and LAT1 and LAT2 Substrates and Inhibitors
    Kantipudi, Satish
    Fotiadis, Dimitrios
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
  • [14] Significance of System L Amino Acid Transporter 1 (LAT-1) and 4F2 Heavy Chain (4F2hc) Expression in Human Developing Intestines
    Ohno, Chikara
    Nakanishi, Yohko
    Honma, Taku
    Henmi, Akihiro
    Sugitani, Masahiko
    Kanai, Yoshikatsu
    Nemoto, Norimichi
    ACTA HISTOCHEMICA ET CYTOCHEMICA, 2009, 42 (03) : 73 - 81
  • [15] IN VITRO CELLULAR AGEING INDUCES CHANGES IN THE EXPRESSION OF RENAL AMINO ACID TRANSPORTER LAT1-4F2HC
    Pinho, M. J.
    Silva, E.
    Cabral, J. M.
    Soares-Da-Silva, P.
    JOURNAL OF HYPERTENSION, 2009, 27 : S149 - S149
  • [16] Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc
    Rosell, Albert
    Meury, Marcel
    Alvarez-Marimon, Elena
    Costa, Meritxell
    Perez-Cano, Laura
    Zorzano, Antonio
    Fernandez-Recio, Juan
    Palacin, Manuel
    Fotiadis, Dimitrios
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (08) : 2966 - 2971
  • [17] Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter
    Balthasar, Christina
    Stangl, Herbert
    Widhalm, Raimund
    Granitzer, Sebastian
    Hengstschlaeger, Markus
    Gundacker, Claudia
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (08)
  • [18] Sub-Nanometer Cryo-EM Density Map of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2
    Jeckelmann, Jean-Marc
    Fotiadis, Dimitrios
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (19) : 1 - 13
  • [19] Establishment of Stable Cell Lines With High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction With α-Alkyl Moieties
    Khunweeraphong, Narakorn
    Nagamori, Shushi
    Wiriyasermku, Pattama
    Nishinaka, Yumiko
    Wongthai, Printip
    Ohgaki, Ryuichi
    Tanaka, Hidekazu
    Tominaga, Hideyuki
    Sakurai, Hiroyuki
    Kanai, Yoshikatsu
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 119 (04) : 368 - 380
  • [20] The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine
    Bröer, A
    Wagner, CA
    Lang, F
    Bröer, S
    BIOCHEMICAL JOURNAL, 2000, 349 : 787 - 795
12345