Identification of chick frizzled-10 expressed in the developing limb and the central nervous system

被引：21
|
作者：
Kawakami, Y
Wada, N
Nishimatsu, S
Komaguchi, C
Noji, S
Nohno, T [1 ]
机构：
[1] Kawasaki Med Sch, Dept Mol Biol, Kurashiki, Okayama 7010192, Japan
[2] Univ Tokushima, Fac Engn, Dept Biol Sci & Technol, Tokushima 7708506, Japan
来源：
MECHANISMS OF DEVELOPMENT | 2000年 / 91卷 / 1-2期
关键词：
frizzled-10; Wnt receptor; Wnt; sonic hedgehog; limb development; epithelial-mesenchymal interaction;
D O I：
10.1016/S0925-4773(99)00301-9
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have identified chick frizzled (Fz)-10, encoding a Wnt receptor, and examined the expression pattern during embryogenesis. Fz-10 is expressed in the region posterior to the Hensen's node at stage 6. Fz-10 expression is detected in the dorsal domain of the neural tube and the central nervous system of the developing embryo. In the developing limb, Fz-10 expression starts at stage 18 in the posterior-dorsal region of the distal mesenchyme, and gradually expands to the anterior-distal region. Fz-10 is also expressed in the feather bud and branchial arch. Implantation of Sonic hedgehog (Shh)-expressing cells into the anterior margin of the limb bud resulted in the induction of Fz-10 expression in anterior-dorsal mesenchyme. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：375 / 378
页数：4
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