Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives

被引：58
|
作者：
Gokçe, M [1 ]
Dogruer, D [1 ]
Sahin, MF [1 ]
机构：
[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey
来源：
FARMACO | 2001年 / 56卷 / 03期
关键词：
6-substituted-3-pyridazinone derivatives; antinociceptive activity; Koster test;
D O I：
10.1016/S0014-827X(01)01037-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test. (C) 2001 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：233 / 237
页数：5
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