Prognostic significance and extra-hypothalamus dysfunction of hyponatremia in anti-leucine-rich glioma-inactivated protein 1 encephalitis

被引：0
|
作者：
Liu, Xiao [1 ,3 ]
Li, Gongfei [1 ,3 ]
Yu, Tingting [1 ,3 ]
Lv, Ruijuan [1 ,3 ]
Cui, Tao [1 ,3 ]
Hogan, R. Edward [2 ,5 ]
Wang, Qun [1 ,3 ,4 ]
机构：
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 119 South 4th Ring Rd, Beijing, Peoples R China
[2] Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA
[3] China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
[4] Capital Med Univ, Beijing Inst Brain Disorders, Collaborat Innovat Ctr Brain Disorders, Beijing, Peoples R China
[5] Washington Univ, Adult Epilepsy Ctr, Sch Med, Dept Neurol, 4921 Parkview Pl Floor 6,Suite C, St Louis, MO 63110 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2022年 / 373卷
基金：
北京市自然科学基金;
关键词：
Leucine-rich glioma-inactivated protein 1; Autoimmune encephalitis; Hyponatremia; Prognosis; Positron emission tomography; DIAGNOSIS; OUTCOMES; LGI1;
D O I：
10.1016/j.jneuroim.2022.578000
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study aimed to investigate prognostic significance and brain metabolic mechanism of hyponatremia in antileucine-rich glioma-inactivated protein 1 (LGI1) encephalitis. After adjusting for confounders, patients with moderate and severe hyponatremia had significantly increased risk of poor functional outcome and sequelae of seizures. In addition, serum sodium was negatively correlated with normalized ratio of the standardized uptake value of medial temporal lobe (MTL), basal ganglia (BG), and hypothalamus on positron emission tomography (PET) and which was further validated using voxel-wise analysis, suggesting an extra-hypothalamus (BG and MTL) localization for hyponatremia.
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页数：9
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