G-CSF in the setting of acute myocardial infarction

被引：0

作者：

Ince, Huseyin ^{[1
]}

Rehders, Tim C. ^{[1
]}

Kische, Stephan ^{[1
]}

Drawert, Stephan ^{[1
]}

Adolf, Esther ^{[1
]}

Kleinfeldt, Tilo ^{[1
]}

Petzsch, Michael ^{[1
]}

Nienaber, Christoph A. ^{[1
]}

机构：

[1] Univ Hosp Rostock, Rostock Sch Med, Dept Med, Div Cardiol, D-18057 Rostock, Germany

来源：

EUROPEAN HEART JOURNAL SUPPLEMENTS | 2006年 / 8卷 / 0H期

关键词：

G-CSF; acute myocardial infarction; cytokines; stem cells;

D O I：

10.1093/eurheartj/sul060

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Experimental data suggest that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) may have potential as a novel regenerative strategy in the setting of acute myocardial infarction (AMI). Potentially beneficial effects of G-CSF may be attributed mainly to direct action of the cytokine G-CSF on injured myocardium by inhibition of apoptosis, rather than to differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews potential cardioprotective effects of G-CSF and discusses experimental and clinical findings with G-CSF in the setting of AMI.

引用

页码：H40 / H45

页数：6

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