Unraveling intestinal stem cell behavior with models of crypt dynamics

被引：63
|
作者：
Carulli, Alexis J. [1 ]
Samuelson, Linda C. [1 ,2 ]
Schnell, Santiago [1 ,3 ]
机构：
[1] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Med, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA
来源：
INTEGRATIVE BIOLOGY | 2014年 / 6卷 / 03期
基金：
美国国家卫生研究院;
关键词：
MOUSE SMALL-INTESTINE; PANETH CELLS; PROGENITOR CELLS; COLORECTAL-CANCER; COLONIC CRYPT; IN-VITRO; EXPRESSION MARKS; ADULT-MOUSE; VILLIN GENE; EPITHELIUM;
D O I：
10.1039/c3ib40163d
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The definition, regulation and function of intestinal stem cells (ISCs) has been hotly debated. Recent discoveries have started to clarify the nature of ISCs, but many questions remain. This review discusses the current advances and controversies of ISC biology as well as theoretical compartmental models that have been coupled with in vivo experimentation to investigate the mechanisms of ISC dynamics during homeostasis, tumorigenesis, repair and development. We conclude our review by discussing the key lingering questions in the field and proposing how many of these questions can be addressed using both compartmental models and experimental techniques.
引用
收藏
页码：243 / 257
页数：15
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