The 5-HT1A antagonist WAY 100635 can block the low-dose locomotor stimulant effects of cocaine

被引：20
|
作者：
Carey, R
Damianopoulos, E
DePalma, G
机构：
[1] VA Med Ctr, Res & Dev 151, Syracuse, NY 13210 USA
[2] SUNY Hlth Sci Ctr, Syracuse, NY 13210 USA
来源：
BRAIN RESEARCH | 2000年 / 862卷 / 1-2期
关键词：
cocaine; locomotion; 5-HT1A receptors; WAY; 100635; dopamine;
D O I：
10.1016/S0006-8993(00)02084-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cocaine treatments of 2.5, 5.0, 10.0 and 15.0 mg/kg induced dose-dependent increases in locomotor behavior. This cocaine-induced increase in locomotion was blocked if the animals were administered the selective 5-HT1A antagonist, WAY 100635 (0.4 mg/kg) prior to the cocaine treatment. The 0.4-mg/kg dose of WAY 100635 did not affect locomotor behavior or alter cocaine availability in brain. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：242 / 246
页数：5
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