The Capacity of Neural Crest-Derived Stem Cells for Ocular Repair

被引：9

作者：

Liu, Bo ^{[1
]}

Hunter, Daniel J. ^{[1
]}

Smith, Andrew A. ^{[1
]}

Chen, Serafine ^{[1
]}

Helms, Jill A. ^{[1
]}

机构：

[1] Stanford Univ, Div Plast & Reconstruct Surg, Dept Surg, Sch Med, Stanford, CA 94305 USA

来源：

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS | 2014年 / 102卷 / 03期

关键词：

neural crest cell; plasticity; neurocristopathy; regeneration; Wnt; stem cell; retina; Muller glia; MULLER GLIA DEDIFFERENTIATION; NEURONAL PROGENITORS; IN-VITRO; REGENERATION; RETINA; EXPRESSION; PROLIFERATION; GROWTH; TISSUE; ORIGINS;

D O I：

10.1002/bdrc.21077

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Whether it is due to a particular epigenetic signature, or some other component of an embryonic differentiation program, accumulating evidence indicates that the origins of a stem cell has a profound impact on the potential of a tissue to regenerate and repair. Here, we focus on Muller glia, long considered the stem cells of the retina, and their surprising derivation from the neural crest. Whether the multipotent properties of a subset of Muller glia is associated with their neural crest origin remains a tantalizing possibility. Birth Defects Research (Part C) 102:299-308, 2014. (c) 2014 Wiley Periodicals, Inc.

引用

页码：299 / 308

页数：10

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