BIODEGRADABLE MATERIALS BASED ON NATURAL SILK FABRIC AS PROMISING SCAFFOLDS FOR TISSUE ENGINEERING AND REGENERATIVE MEDICINE

被引：0
|
作者：
Safonova, L. A. [1 ]
Bobrova, M. M. [1 ]
Efimov, A. E. [1 ]
Agapova, O., I [1 ]
Agapov, I. I. [1 ]
机构：
[1] Shumakov Natl Med Res Ctr Transplantol & Artifici, Moscow, Russia
来源：
VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV | 2020年 / 22卷 / 04期
关键词：
silk; natural silk fabric; biodegradable scaffolds; biodegradation rate; FIBROIN; MICROSPHERES; GELATIN;
D O I：
10.15825/1995-1191-2020-4-105-114
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Objective: to develop a method for obtaining scaffolds based on natural silk fabric and to study their biocompatibility in vitro. Materials and methods. To obtain biodegradable scaffolds based on natural silk fabric, we propose treating natural silk fabric with a water-ethanol solution of calcium chloride. Differences in the structure of the resulting scaffolds were identified via scanning electron microscopy. Conclusion. The resulting scaffolds are non-toxic to cells and support cell adhesion and proliferation. Our studies make it possible to consider the resulting biodegradable scaffolds as promising constructs for tissue engineering and regenerative medicine.
引用
收藏
页码：105 / 114
页数：10
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