The role of zinc and its compounds in leukemia

被引：25
|
作者：
Orlov, Alexey P. [1 ]
Orlova, Marina A. [1 ,2 ]
Trofimova, Tatiana P. [1 ,3 ]
Kalmykov, Stepan N. [1 ]
Kuznetsov, Dmitry A. [4 ]
机构：
[1] Lomonosov Moscow State Univ, Dept Chem, 1,Bd 3 Leninskie Gory, Moscow 119992, Russia
[2] Dmitry Rogachev Med Natl Res Ctr Pediat Hematol O, Biochem & Pharmacol Div, 1 Samory Mashela St, Moscow 117997, Russia
[3] Inst Physiol Act Cpds RAS, Dept Organ Synth, North Pass 1, Moscow 142432, Russia
[4] Pirogov Russian Natl Res Med Univ, 1 Ostrovityanova St, Moscow 117997, Russia
来源：
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 2018年 / 23卷 / 03期
关键词：
Zinc; Signaling pathway; Zinc fingers; Metallothioneins; Zinc complexes; Zinc salicylates; Zinc chelation; ACUTE LYMPHOBLASTIC-LEUKEMIA; HUMAN SERUM-ALBUMIN; HISTONE DEACETYLASE INHIBITORS; CRYSTAL-STRUCTURE; DOWN-REGULATION; REGULATOR PLZF; BINDING GROUPS; METAL-BINDING; ACTIVE-SITE; FINGER;
D O I：
10.1007/s00775-018-1545-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Zinc is one of the most important microelements necessary for normal body functioning. Zinc is marked in numerous diseases and, hence, its properties and behavior in the body have long been a subject of extensive study. This review considers trends in the assessment of the role of zinc and its compounds in the past decade. It becomes evident that redox-inactive zinc is the main supervisor in the conformation of the most important molecules in all body organs and tissues. We placed emphasis on the variety of zinc-binding sites and the role of zinc in the genesis and progress of different forms of leukemia. The importance of some families of transcription factors in the development and prognosis of treatment of various leukemia forms is examined; new directions of these studies are shown.
引用
收藏
页码：347 / 362
页数：16
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