The congenital cytomegalovirus infection: Virus-host interaction for defense and transmission

被引:8
|
作者
Halwachs-Baumann, Gabriele [1 ]
机构
[1] Med Univ Graz, Dept Lab Med, A-8036 Graz, Austria
关键词
D O I
10.2174/138920106777950780
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The congenital CMV infection is the most common intrauterine transmitted viral infection. Since the first description in 1904 a lot of knowledge on epidemiology has been gained. Socio-economic maternal factors play a major role, and seem to be one of the major reasons for the differences of prevalence of congenital CMV infection between Europe and North America. Concerning the interaction of CMV and placental cells, reactions of the host immune system have a dual effect - protection against the virus on the one hand, and supporting of virus production and release of CMV on the other hand. In the last years new strategies for prevention and therapy of congenital CMV infection have been investigated. Passive immunization for prevention of transmission of the virus seems to be promising, but also therapy with ganciclovir of congenital infected newborns showed good results. Taking the side effects of antiviral therapy into consideration, active and passive immunization may ultimately be the best control strategy for this important public health problem.
引用
收藏
页码:303 / 312
页数:10
相关论文
共 50 条
  • [31] Virus-Host Interactions in Foot-and-Mouth Disease Virus Infection
    Li, Kangli
    Wang, Congcong
    Yang, Fan
    Cao, Weijun
    Zhu, Zixiang
    Zheng, Haixue
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [32] Virus-host interaction in the simian immunodeficiency virus-infected brain
    Fox, Howard S.
    JOURNAL OF NEUROVIROLOGY, 2008, 14 (04) : 286 - 291
  • [33] Mechanisms of DNA Methylation in Virus-Host Interaction in Hepatitis B Infection: Pathogenesis and Oncogenetic Properties
    Zhang, Dake
    Guo, Shicheng
    Schrodi, Steven J.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (18)
  • [34] Deciphering the role of soluble ORF2 protein in virus-host interaction in HEV infection
    Maas, Michelle
    Neumann-Haefelin, Christoph
    HEPATOLOGY, 2023, 78 (06) : 1692 - 1694
  • [35] Virus-host interactions
    Cohen, S
    ASM NEWS, 1999, 65 (06): : 388 - 389
  • [36] VIRUS-HOST SPECIFICITY
    DEZOETEN, GA
    PHYTOPATHOLOGY, 1983, 73 (05) : 768 - 768
  • [37] New insights into hepatitis E virus virus-host interaction: interplay with host interferon induction
    Wu, Chunyan
    Nan, Yuchen
    Zhang, Yan-Jin
    FUTURE VIROLOGY, 2015, 10 (04) : 439 - 448
  • [38] Viral Circular RNAs and Their Possible Roles in Virus-Host Interaction
    Zhang, Xing
    Liang, Zi
    Wang, Chonglong
    Shen, Zeen
    Sun, Sufei
    Gong, Chengliang
    Hu, Xiaolong
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [39] Defective viral genomes are key drivers of the virus-host interaction
    Vignuzzi, Marco
    Lopez, Carolina B.
    NATURE MICROBIOLOGY, 2019, 4 (07) : 1075 - 1087
  • [40] Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction
    Lei, Xiaobo
    Xiao, Xia
    Wang, Jianwei
    VIRUSES-BASEL, 2016, 8 (01):