Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for Cancer Immunotherapy

被引:132
|
作者
Chester, Cariad [1 ,2 ]
Fritsch, Katherine [1 ]
Kohrt, Holbrook E. [1 ]
机构
[1] Stanford Univ, Dept Med, Div Oncol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Inst Immun Transplantat & Infect, Stanford, CA 94305 USA
来源
FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷
关键词
natural killer cells; immunotherapy; adoptive cell therapy; monoclonal antibody; cancer vaccines; checkpoint blockade; TUMOR-NECROSIS-FACTOR; NK CELL; MONOCLONAL-ANTIBODY; HLA-E; MEDIATED CYTOTOXICITY; DENDRITIC CELLS; PHASE-1; TRIAL; MISSING SELF; IFN-GAMMA; IN-VIVO;
D O I
10.3389/fimmu.2015.00601
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
There is compelling clinical and experimental evidence to suggest that natural killer (NK) cells play a critical role in the recognition and eradication of tumors. Efforts at using NK cells as antitumor agents began over two decades ago, but recent advances in elucidating NK cell biology have accelerated the development of NK cell-targeting therapeutics. NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors. In the early phases of cancer immune surveillance, NK cells directly identify and lyse cancer cells. Nascent transformed cells elicit NK cell activation and are eliminated. However, as tumors progress, cancerous cells develop immunosuppressive mechanisms that circumvent NK cell-mediated killing, allowing for tumor escape and proliferation. Therapeutic intervention aims to reverse tumor-induced NK cell suppression and sustain NK cells' tumorlytic capacities. Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study
    Hanan Fouad
    Maissa Saeed El Raziky
    Rasha Ahmed Abdel Aziz
    Dina Sabry
    Ghada Mahmoud Abdel Aziz
    Manal Ewais
    Ahmed Reda Sayed
    World Journal of Gastroenterology, 2013, 19 (43) : 7711 - 7718
  • [42] Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study
    Fouad, Hanan
    El Raziky, Maissa Saeed
    Aziz, Rasha Ahmed Abdel
    Sabry, Dina
    Aziz, Ghada Mahmoud Abdel
    Ewais, Manal
    Sayed, Ahmed Reda
    WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (43) : 7711 - 7718
  • [43] Co-Stimulatory Signaling Boosts CAR T Cell Efficacy Against CLL
    Zhao, Ziran
    Collins, McKensie
    Sun, Clare
    Wiestner, Adrian
    Melenhorst, J. Joseph
    BLOOD, 2022, 140 : 10255 - 10256
  • [44] Improving natural killer cell cancer immunotherapy
    Berrien-Elliott, Melissa M.
    Romee, Rizwan
    Fehniger, Todd A.
    CURRENT OPINION IN ORGAN TRANSPLANTATION, 2015, 20 (06) : 671 - 680
  • [45] Natural killer cell engagers for cancer immunotherapy
    Nikkhoi, Shahryar Khoshtinat
    Li, Geng
    Hatefi, Arash
    FRONTIERS IN ONCOLOGY, 2025, 14
  • [46] Targeting Adenosine Receptor Signaling in Cancer Immunotherapy
    Sek, Kevin
    Molck, Christina
    Stewart, Gregory D.
    Kats, Lev
    Darcy, Phillip K.
    Beavis, Paul A.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (12)
  • [47] ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation
    Ghosh, Shirsendu
    Di Bartolo, Vincenzo
    Tubul, Liron
    Shimoni, Eyal
    Kartvelishvily, Elena
    Dadosh, Tali
    Feigelson, Sara W.
    Alon, Ronen
    Alcover, Andres
    Haran, Gilad
    CELL REPORTS, 2020, 30 (10): : 3434 - +
  • [48] The Potential for Cancer Immunotherapy in Targeting Surgery-Induced Natural Killer Cell Dysfunction
    Market, Marisa
    Baxter, Katherine E.
    Angka, Leonard
    Kennedy, Michael A.
    Auer, Rebecca C.
    CANCERS, 2019, 11 (01):
  • [49] Mechanistic Modeling of Co-stimulatory and Co-inhibitory Surface Molecules Effect on Cell-to-cell Interactions
    Demin, Oleg, Jr.
    JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2017, 44 : S68 - S68
  • [50] Regulation of natural killer cell stimulatory and inhibitory molecules in mouse nervous system
    Backström, E
    Drenth, AFJ
    Sjölin, H
    Ljunggren, HG
    Kristensson, K
    JOURNAL OF NEUROIMMUNOLOGY, 2004, 154 (1-2) : 205 - 205