Functional rafts in cell membranes

被引：8022
作者：
Simons, K [1 ]
Ikonen, E [1 ]
机构：
[1] NATL PUBL HLTH INST, DEPT BIOCHEM, SF-00300 HELSINKI, FINLAND
来源：
NATURE | 1997年 / 387卷 / 6633期
关键词：
D O I：
10.1038/42408
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed that these rafts function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
引用
收藏
页码：569 / 572
页数：4
相关论文
共 67 条
[1]   Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae [J].
Anderson, HA ;
Chen, YZ ;
Norkin, LC .
MOLECULAR BIOLOGY OF THE CELL, 1996, 7 (11) :1825-1834
[2]   POTOCYTOSIS - SEQUESTRATION AND TRANSPORT OF SMALL MOLECULES BY CAVEOLAE [J].
ANDERSON, RGW ;
KAMEN, BA ;
ROTHBERG, KG ;
LACEY, SW .
SCIENCE, 1992, 255 (5043) :410-411
[3]   CAVEOLAE - WHERE INCOMING AND OUTGOING MESSENGERS MEET [J].
ANDERSON, RGW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) :10909-10913
[4]   LIPID INTERMOLECULAR HYDROGEN-BONDING - INFLUENCE ON STRUCTURAL ORGANIZATION AND MEMBRANE-FUNCTION [J].
BOGGS, JM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 906 (03) :353-404
[5]   DO THE LONG FATTY-ACID CHAINS OF SPHINGOLIPIDS INTERDIGITATE ACROSS THE CENTER OF A BILAYER OF SHORTER CHAIN SYMMETRICAL PHOSPHOLIPIDS [J].
BOGGS, JM ;
KOSHY, KM .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1994, 1189 (02) :233-241
[6]   CHOLESTEROL AND THE GOLGI-APPARATUS [J].
BRETSCHER, MS ;
MUNRO, S .
SCIENCE, 1993, 261 (5126) :1280-1281
[7]   SORTING OF GPI-ANCHORED PROTEINS TO GLYCOLIPID-ENRICHED MEMBRANE SUBDOMAINS DURING TRANSPORT TO THE APICAL CELL-SURFACE [J].
BROWN, DA ;
ROSE, JK .
CELL, 1992, 68 (03) :533-544
[8]   PROTEIN LIPIDATION IN CELL SIGNALING [J].
CASEY, PJ .
SCIENCE, 1995, 268 (5208) :221-225
[9]  
CERNEUS DP, 1993, J BIOL CHEM, V268, P3150
[10]   EVIDENCE FOR REGULAR DISTRIBUTION OF STEROLS IN LIQUID-CRYSTALLINE PHOSPHATIDYLCHOLINE BILAYERS [J].
CHONG, PLG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :10069-10073
1234567