Place of birth and risk of gallbladder cancer in India

被引:30
|
作者
Mhatre, S. S. [1 ]
Nagrani, R. T. [1 ]
Budukh, A. [1 ]
Chiplunkar, S. [4 ]
Badwe, R. [2 ]
Patil, P. [3 ]
Laversanne, M. [5 ]
Rajaraman, P. [6 ]
Bray, F.
Dikshit, R. [1 ]
机构
[1] Tata Mem Hosp, Ctr Canc Epidemiol, Mumbai, Maharashtra, India
[2] Tata Mem Hosp, Dept Surg Oncol, Mumbai, Maharashtra, India
[3] Tata Mem Hosp, Dept Digest Dis & Clin Nutr, Mumbai, Maharashtra, India
[4] Tata Mem Hosp, Adv Ctr Treatment Res & Educ Canc, Chiplunkar Lab, Navi Mumbai, Maharashtra, India
[5] Int Agcy Res Canc, Sect Canc Surveillance, Lyon, France
[6] NCI, Ctr Global Hlth, NIH, DHSS, Bethesda, MD 20892 USA
关键词
Birth region; gallbladder cancer; population-based cancer registries;
D O I
10.4103/0019-509X.197723
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
CONTEXT: Within India, the incidence of gallbladder cancer (GBC) is characterized by marked geographical variation; however, the reasons for these differences are unclear. AIMS: To evaluate the role of place of birth, length of residence, and effect of migration from high-to low-risk region on GBC development. SETTINGS AND DESIGN: Population-based cancer registries (PBCRs); case-control study. SUBJECTS AND METHODS: Data of PBCRs were used to demonstrate geographical variation in GBC incidence rates. A case-control study data examined the role of birth place, residence length, and effect of migration in etiology of GBC. STATISTICAL ANALYSIS: Rate ratios for different PBCRs were estimated using Chennai Cancer Registry as the reference population. Odds ratios (ORs) for developing GBC in a high-risk region compared to a low-risk region and associated 95% confidence interval (CI) were estimated through unconditional logistic regression models using case-control study. RESULTS: GBC shows marked variation in incidence with risk highest in Northeast regions and lowest in South India. OR of 4.82 (95% CI: 3.87-5.99) was observed for developing GBC for individuals born in a high-risk region compared to those born in a low-risk region after adjusting for confounders. A dose-response relationship with increased risk with increased length of residence in a high-risk region was observed (OR lifetime 5.58 [95% CI: 4.42-7.05]; P-trend <= 0.001). The risk persisted even if study participant migrated from high-to low-risk region (OR = 1.36; 95% CI: 1.02-1.82). CONCLUSIONS: The present study signifies the importance of place of birth, length of stay, and effect of migration from high-to low-risk region in the development of GBC. The data indicate role of environmental and genetic factors in etiology of disease.
引用
收藏
页码:304 / 308
页数:5
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