Chiral epoxides by desymmetrizing deprotonation of meso-epoxides

被引：0

作者：

Hodgson, DM ^{[1
]}

Gras, E ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 13期

关键词：

D O I：

10.1002/1521-3773(20020703)41:13<2376::AID-ANIE2376>3.0.CO;2-Q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simple meso-epoxides can be asymmetrically functionalized: Ligand-assisted direct hydrogen-lithium exchange allows the generation of destabilized oxiranyl lithium species and their subsequent trapping by a wide array of electrophiles (see scheme; E = group formed by addition of electrophile). When carried out in the presence of (-)-sparteine as ligand, this reaction provides a new enantioselective route to epoxides.

引用

页码：2376 / 2378

页数：3

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