Chiral epoxides by desymmetrizing deprotonation of meso-epoxides

被引：0
|
作者：
Hodgson, DM [1 ]
Gras, E [1 ]
机构：
[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 13期
关键词：
D O I：
10.1002/1521-3773(20020703)41:13<2376::AID-ANIE2376>3.0.CO;2-Q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Simple meso-epoxides can be asymmetrically functionalized: Ligand-assisted direct hydrogen-lithium exchange allows the generation of destabilized oxiranyl lithium species and their subsequent trapping by a wide array of electrophiles (see scheme; E = group formed by addition of electrophile). When carried out in the presence of (-)-sparteine as ligand, this reaction provides a new enantioselective route to epoxides.
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页码：2376 / 2378
页数：3
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