Remarkably stable tetrahedral intermediates:: Carbinols from nucleophilic additions to N-acylpyrroles

被引：0
|
作者：
Evans, DA [1 ]
Borg, G [1 ]
Scheidt, KA [1 ]
机构：
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 17期
关键词：
D O I：
10.1002/1521-3773(20020902)41:17<3188::AID-ANIE3188>3.0.CO;2-H
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sufficiently stable intermediates formed in the reaction of N-acylpyrroles (1) with hydride and Grignard reagents can undergo further synthetic transformations and chromatographic purification to enable the generation of pyrrolecarbinols 2 in 76-95% yields [Eq. (1)].
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页码：3188 / +
页数：5
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