HIV therapy in the post-eradication era

被引:0
|
作者
Vella, S [1 ]
Palmisano, L [1 ]
机构
[1] Ist Super Sanita, Virol Lab, Reparto Infez Retrovirus, I-00161 Rome, Italy
来源
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2000年 / 14卷 / 01期
关键词
human immunodeficiency virus; antiretroviral therapy; eradication; interleukin-2; immunologic control;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Over the past three years, most efforts of virologists and immunologists involved in the field of Human Immunodeficiency Virus (HIV) have been focussed on strategies aimed at eradicating the infection. So far, however, all the approaches have been unsuccessful. Indeed, even if the currently available potent antiretroviral regimens are able to induce a profound and durable suppression of viral replication, they have poor effect on a viral reservoir of latently infected CD4+ T lymphocytes that rapidly reactivate after treatment discontinuation. Different approaches, including combined (immune based and antiretroviral) therapies, are therefore under investigation. The goal is to achieve an equilibrium where virus-induced immune dysfunction is prevented by an effective anti HIV immune response.
引用
收藏
页码:34 / 37
页数:4
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