Radiation-chemical transformations of coumarins in ethanolic solutions

被引：11
|
作者：
Samovich, S. N. [1 ,2 ]
Brinkevich, S. D. [1 ]
Edimecheva, I. P. [2 ]
Shadyro, O. I. [1 ,2 ]
机构：
[1] Belarusian State Univ, Dept Chem, Minsk 220030, BELARUS
[2] Belarusian State Univ, Res Inst Phys Chem Problems, Minsk 220006, BELARUS
来源：
RADIATION PHYSICS AND CHEMISTRY | 2014年 / 100卷
关键词：
Steady state radiolysis; alpha-Hydroxyethyl radical; Coumarin; Radical scavenger; LIPID-PEROXIDATION; HOMOLYTIC CLEAVAGE; PHENOLIC-COMPOUNDS; IN-VIVO; DERIVATIVES; FRAXETIN; FRAGMENTATION; SUPEROXIDE; RADIOLYSIS; CANCER;
D O I：
10.1016/j.radphyschem.2014.03.015
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Effects of coumarin and its derivatives on product formation during radiolysis of deaerated and oxygenated ethanol were investigated. The data obtained in this study indicate that coumarin, 4-hydroxycoumarin and warfarin effectively oxidized alpha-hydroxyethyl radicals (alpha-HER), while esculetin and fraxetin predominantly reduced the above named intermediates. Coumarin, esculetin and fraxetin were able to add alpha-HER to the double carbon-carbon bond of the pyrone ring to form stable products with molecular masses exceeding those of the starting molecules. Coumarin, warfarin, esculetin and fraxetin were shown to display antioxidant activity during radiation-induced oxidation of ethanol. (C) 2014 Elsevier Ltd. All rights reserved.
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页码：13 / 22
页数：10
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