Enantiomeric discrimination of α-hydroxy acids and N-Ts-α-amino acids by 1H NMR spectroscopy

被引：10
|
作者：
Gao, Guangpeng [1 ]
Lv, Caixia [1 ]
Li, Qiuju [1 ]
Ai, Lin [1 ]
Zhang, Jiaxin [1 ]
机构：
[1] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 48期
关键词：
Enantiomeric discrimination; alpha-Hydroxy acids and N-Ts-alpha-amino acids; H-1 NMR spectroscopy; CHIRAL SOLVATING AGENTS; CARBOXYLIC-ACIDS; ENANTIOSELECTIVE RECOGNITION; ABSOLUTE-CONFIGURATION; SHIFT-REAGENT; MANDELIC-ACID; CROWN MACROCYCLES; NMR DETERMINATION; BEARING; DERIVATIVES;
D O I：
10.1016/j.tetlet.2015.10.060
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new kind of chiral compounds with multiple amino, amido and phenolic hydroxy groups has been synthesized from D-phenylalanine and D-phenylglycine, respectively. The enantiomeric discriminations of alpha-hydroxy acids and N-Ts-alpha-amino acids have been finished in the presence of the above chiral compounds as chiral solvating agents by H-1 NMR spectroscopy. The results show that the chiral compounds are highly effective and practical chiral solvating agents towards alpha-hydroxy acids and N-Ts-alpha-amino acids. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6742 / 6746
页数：5
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