Expression of an Oncogenic ERG isoform Characterizes a Distinct Subtype of B-Progenitor Acute Lymphoblastic Leukemia

被引:1
|
作者
Zhang, Jinghui [1 ]
McCastlain, Kelly [2 ]
Qu, Chunxu [1 ]
Wu, Gang [1 ]
Edmonson, Michael [1 ]
Li, Yongjin [1 ]
Wei, Lei [2 ]
Payne-Turner, Debbie [2 ]
Yoshihara, Hiroki [2 ]
Churchman, Michelle L. [2 ]
Waanders, Esme [2 ,3 ,4 ]
Ntziachristos, Panagiotis [5 ]
Aifantis, Iannis [5 ,6 ]
Roberts, Kathryn G. [2 ]
Ma, Jing [2 ]
Song, Guangchun [2 ]
Easton, John [7 ]
Mulder, Heather L. [7 ]
Chen, Xiang [1 ]
Rusch, Michael [1 ]
Boggs, Kristy [7 ]
Vadodaria, Bhavin [7 ]
Dalton, James [2 ]
Valentine, Marcus L. [8 ]
Ding, Li [9 ]
Lu, Charles [9 ]
Fulton, Robert S. [9 ]
Fulton, Lucinda [9 ]
Tabib, Yashodan [9 ]
Ochoa, Kerri [9 ]
Devidas, Meenakshi [10 ,11 ,12 ]
Pei, Deqing [13 ]
Cheng, Cheng [13 ]
Evans, William E. [14 ]
Pui, Ching-Hon [15 ]
Jeha, Sima [16 ]
Harvey, Richard C. [17 ]
Chen, I-Ming L. [17 ]
Willman, Cheryl L. [17 ]
Marcucci, Guido [18 ]
Bloomfield, Clara D. [19 ]
Kohlschmidt, Jessica [19 ]
Mrozek, Krzysztof [19 ]
Paietta, Elisabeth [20 ]
Tallman, Martin S. [21 ]
Stock, Wendy [22 ]
Voorhees, Peter M. [23 ]
Racevskis, Janis [24 ]
Rowe, Jacob M. [25 ]
Luger, Selina [26 ]
机构
[1] St Jude Childrens Res Hosp, Dept Computat Biol, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA
[3] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands
[4] Radboud Ctr Mol Life Sci, Nijmegen, Netherlands
[5] NYU, Dept Pathol, New York, NY 10016 USA
[6] Howard Hughes Med Inst, New York, NY USA
[7] St Jude Childrens Res Hosp, Pediat Canc Genome Project, Memphis, TN 38105 USA
[8] St Jude Childrens Res Hosp, Cytogenet Core Facil, Memphis, TN 38105 USA
[9] Washington Univ, McDonnell Genome Inst, St Louis, MO USA
[10] Univ Florida, Coll Med, Dept Biostat, Gainesville, FL USA
[11] Univ Florida, Coll Publ Hlth, Dept Biostat, Gainesville, FL USA
[12] Univ Florida, Coll Hlth Profess, Dept Biostat, Gainesville, FL USA
[13] St Jude Childrens Res Hosp, Dept Biostat, Memphis, TN 38105 USA
[14] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA
[15] St Jude Childrens Res Hosp, Oncol, Memphis, TN 38105 USA
[16] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA
[17] Univ New Mexico, Dept Pathol, Canc Res & Treatment Ctr, Albuquerque, NM 87131 USA
[18] City Hope Natl Med Ctr, Gehr Leukemia Ctr, Duarte, CA USA
[19] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[20] Montefiore Med Ctr, Ctr Canc, North Div, Bronx, NY 10467 USA
[21] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[22] Univ Chicago, Med Ctr, Chicago, IL 60637 USA
[23] Univ N Carolina, Div Hematol Oncol, Chapel Hill, NC USA
[24] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med Oncol, New York, NY USA
[25] Shaare Zedek Med Ctr, Dept Hematol, Jerusalem, Israel
[26] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
[27] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Sect Mol Hematol & Therapy, Houston, TX 77030 USA
[28] Washington Univ, Sch Med, St Louis, MO USA
[29] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA
[30] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
[31] Univ Calif San Francisco, Dept Pediat, Benioff Childrens Hosp, San Francisco, CA USA
关键词
D O I
10.1182/blood.V126.23.693.693
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [41] A LOW REDOX STATE CHARACTERIZES A DISTINCT SUBSET OF BLASTS WITH PROGENITOR/'STEM - LIKE' PROPERTIES IN ACUTE MYELOID LEUKEMIA
    Lagadinou, E. D.
    Kokkinou, D.
    Themeli, M.
    Dimas, K.
    Spyridonidis, A.
    Zoumbos, N. C.
    EXPERIMENTAL HEMATOLOGY, 2009, 37 (09) : S43 - S43
  • [42] Mutations in the B-Cell transcription factor PAX5 found in B-Progenitor acute lymphoblastic leukemia impair normal PAX5 activity.
    Miller, Christopher B.
    Mullighan, Charles G.
    Downing, James R.
    BLOOD, 2006, 108 (11) : 185A - 185A
  • [43] Characterization of PAX5 Mutations in B Progenitor Acute Lymphoblastic Leukemia
    Jia, Zhilian
    Hu, Zunsong
    Damirchi, Behzad
    Han, Than Than
    Gu, Zhaohui
    BLOOD, 2022, 140 : 1001 - 1002
  • [44] Mature B-cell acute lymphoblastic leukemia with t(9;11) translocation: a distinct subset of B-cell acute lymphoblastic leukemia
    Tsao, L
    Draoua, HY
    Osunkwo, I
    Nandula, SV
    Murty, VVS
    Mansukhani, M
    Bhagat, G
    Alobeid, B
    MODERN PATHOLOGY, 2004, 17 (07) : 832 - 839
  • [45] New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia
    Lilljebjorn, Henrik
    Fioretos, Thoas
    BLOOD, 2017, 130 (12) : 1395 - 1401
  • [46] Oncogenic lesions and molecular subtypes in adults with B-cell acute lymphoblastic leukemia
    Yasuda, Takahiko
    Sanada, Masashi
    Tsuzuki, Shinobu
    Hayakawa, Fumihiko
    CANCER SCIENCE, 2023, 114 (01) : 8 - 15
  • [47] Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia
    Bohne, Arend
    Schlee, Cornelia
    Mossner, Max
    Thibaut, Julia
    Heesch, Sandra
    Thiel, Eckhard
    Hofmann, Wolf-Karsten
    Baldus, Claudia D.
    LEUKEMIA RESEARCH, 2009, 33 (06) : 817 - 822
  • [48] TEL/AML1 fusion occurs in 28% of pediatric B-progenitor cell acute lymphoblastic leukemia (ALL) and defines a subgroup of patients with a favorable prognosis.
    Shurtleff, SA
    Buijs, A
    Behm, FG
    Rubnitz, JE
    Raimondi, SC
    Hancock, ML
    Head, DR
    Pui, CH
    Grosveld, G
    Downing, JR
    BLOOD, 1995, 86 (10) : 2378 - 2378
  • [49] CLONAL DEVELOPMENT FROM A PROGENITOR WITH RESTRICTED DIFFERENTIATIVE EXPRESSION IN ACUTE LYMPHOBLASTIC-LEUKEMIA
    FERRARIS, AM
    CANEPA, L
    MASSIMO, L
    DINI, G
    BROCCIA, G
    MELONI, T
    FORTELEONI, G
    MELANI, C
    GAETANI, GF
    AMERICAN JOURNAL OF HEMATOLOGY, 1985, 20 (01) : 81 - 83
  • [50] Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
    Ferrando, AA
    Neuberg, DS
    Staunton, J
    Loh, ML
    Huard, C
    Raimondi, SC
    Behm, FG
    Pui, CH
    Downing, JR
    Gilliland, DG
    Lander, ES
    Golub, TR
    Look, AT
    CANCER CELL, 2002, 1 (01) : 75 - 87