Role of Nod2 in the development of Crohn's disease

被引：58
|
作者：
Yamamoto, Soichiro [1 ]
Ma, Xiaojing [1 ]
机构：
[1] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA
来源：
MICROBES AND INFECTION | 2009年 / 11卷 / 12期
关键词：
Crohn's disease; Inflammation; Homeostasis; Interleukin-10; Monocytes; Macrophages; Nod2; 1007fs; R702W; G908R; Interleukin-12; Interleukin-23; Mucosal immunity; TLR; Commensals; FRAMESHIFT MUTATION; MURAMYL DIPEPTIDE; NOD2/CARD15; GENE; IMMUNE-SYSTEM; INTERLEUKIN-10; IL-10; PATHOGENESIS; SUSCEPTIBILITY; MACROPHAGES; ASSOCIATION;
D O I：
10.1016/j.micinf.2009.06.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Crohn's Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：912 / 918
页数：7
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