Effects of norepinephrine depletion in rats during cerebral post-ischemic reperfusion

被引：3
|
作者：
Martinez, G
Di Giacomo, C
Sorrenti, V
Carnazza, ML
Bisceglie, V
Vanella, A
机构：
[1] Univ Catania, Fac Pharm, Dept Biol Chem, I-95125 Catania, Italy
[2] Univ Catania, Fac Med, Dept Anat Diagnost Pathol Legal Med & Publ Hlth G, I-95123 Catania, Italy
[3] Fac Med, Dept Mycrobiol & Gynecol, Catania, Italy
来源：
NEUROTOXICOLOGY | 2004年 / 25卷 / 05期
关键词：
DSP-4; cerebral post-ischemic reperfusion; NA; 5-HT;
D O I：
10.1016/j.neuro.2003.12.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present paper reports the effects of norepinephrine depletion in rats, after treatment with N-(2-chloroethyl)-N-ethyl 2-bromobenzylamine (DSP-4) neurotoxin, on partial cerebral ischemia and reperfusion. Histological observations made under experimental conditions of noradrenergic (NA)-depletion demonstrated that neuronal lesions were not exacerbated; in fact, in DSP-4-treated ischemic animals, a minor number of neurons appeared damaged. Our results suggest that neuronal recovery after post-ischemic reperfusion is not affected by NA-depletion. DSP-4 neurotoxin does not induce 5-hydroxy-triptamine (5-HT) depletion. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：877 / 884
页数：8
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