Labdane Diterpenoids from the Roots of Amomum maximum and Their Cytotoxic Evaluation

被引：20

作者：

Luo, Jian-Guang ^{[1
]}

Yin, Hong ^{[1
]}

Fan, Bo-Yi ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Dept Nat Med Chem, Nanjing 210009, Jiangsu, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2014年 / 97卷 / 08期

基金：

中国国家自然科学基金;

关键词：

FRUITS;

D O I：

10.1002/hlca.201300426

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rare labdane diterpene gamma-lactam, 1, and two new labdane diterpenoids, 2 and 3, along with two known diterpenes, 4 and 5, were isolated from the roots of Amomum maximum. Their structures were established on the basis of spectroscopic data. All of the isolates were evaluated for their cytotoxic activities, and compound 3 was found to exhibit an inhibitory activity against MG-63 cell lines with an IC50 value of 3.3 +/- 0.8 mu g/ml.

引用

页码：1140 / 1145

页数：6

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