Labdane Diterpenoids from the Roots of Amomum maximum and Their Cytotoxic Evaluation

被引：20

作者：

Luo, Jian-Guang ^{[1
]}

Yin, Hong ^{[1
]}

Fan, Bo-Yi ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Dept Nat Med Chem, Nanjing 210009, Jiangsu, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2014年 / 97卷 / 08期

基金：

中国国家自然科学基金;

关键词：

FRUITS;

D O I：

10.1002/hlca.201300426

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rare labdane diterpene gamma-lactam, 1, and two new labdane diterpenoids, 2 and 3, along with two known diterpenes, 4 and 5, were isolated from the roots of Amomum maximum. Their structures were established on the basis of spectroscopic data. All of the isolates were evaluated for their cytotoxic activities, and compound 3 was found to exhibit an inhibitory activity against MG-63 cell lines with an IC50 value of 3.3 +/- 0.8 mu g/ml.

引用

页码：1140 / 1145

页数：6

共 50 条

[1] Tetracyclic Diterpenoids with Isomerized Isospongian Skeleton and Labdane Diterpenoids from the Fruits of Amomum kravanh
Yin, Hong
Luo, Jian-Guang
Kong, Ling-Yi
JOURNAL OF NATURAL PRODUCTS, 2013, 76 (02): : 237 - 242
[2] Cytotoxic labdane diterpenoids from Croton oblongifolius
Roengsumran, S
Petsom, A
Kuptiyanuwat, N
Vilaivan, T
Ngamrojnavanich, N
Chaichantipyuth, C
Phuthong, S
PHYTOCHEMISTRY, 2001, 56 (01) : 103 - 107
[3] Maximumins A-D, Rearranged Labdane-Type Diterpenoids with Four Different Carbon Skeletons from Amomum maximum
Ji, Kai-Long
Fan, Yao-Yue
Ge, Zhan-Peng
Sheng, Li
Xu, You-Kai
Gang, Li-She
Li, Jing-Ya
Yue, Jian-Min
JOURNAL OF ORGANIC CHEMISTRY, 2019, 84 (01): : 282 - 288
[4] Labdane and Abietane Diterpenoids from Juniperus oblonga and Their Cytotoxic Activity
Qiao, Yilin
Khutsishvili, Manana
Alizade, Valida
Atha, Daniel
Borris, Robert P.
MOLECULES, 2019, 24 (08)
[5] NOVEL CYTOTOXIC LABDANE DITERPENOIDS FROM NEOUVARIA-ACUMINATISSIMA
LEE, IS
MA, XJ
CHAI, HB
MADULID, DA
LAMONT, RB
ONEILL, MJ
BESTERMAN, JM
FARNSWORTH, NR
SOEJARTO, DD
CORDELL, GA
PEZZUTO, JM
KINGHORN, AD
TETRAHEDRON, 1995, 51 (01) : 21 - 28
[6] Kaurane and abietane diterpenoids from the roots of Tripterygium wilfordii and their cytotoxic evaluation
Gao, Chang
Wang, Di
Zhang, Yan
Huang, Xiao-Xiao
Song, Shao-Jiang
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (12) : 2942 - 2946
[7] Cytotoxic diterpenoids from the roots of Salvia lachnocalyx
Hossein Hadavand Mirzaei
Omidreza Firuzi
Bernd Schneider
Ian T. Baldwin
Amir Reza Jassbi
Revista Brasileira de Farmacognosia, 2017, 27 : 475 - 479
[8] Cytotoxic diterpenoids from the roots of Euphorbia stracheyi
Ye, Ye
Liu, Guang-Hui
Dawa, Drolma
Ding, Li-Sheng
Cao, Zhi-Xing
Zhou, Yan
PHYTOCHEMISTRY LETTERS, 2020, 36 : 183 - 187
[9] Cytotoxic Diterpenoids from the Roots of Aralia melanocarpa
Jiang, Zhi-Yong
Yang, Chun-Tao
Hou, Shu-Qun
Tian, Kai
Wang, Wei
Hu, Qiu-Fen
Huang, Xiang-Zhong
PLANTA MEDICA, 2016, 82 (08) : 742 - 746
[10] Cytotoxic diterpenoids from the roots of Salvia lachnocalyx
Mirzaei, Hossein Hadavand
Firuzi, Omidreza
Schneider, Bernd
Baldwin, Ian T.
Jassbi, Amir Reza
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2017, 27 (04): : 475 - 479

← 1 2 3 4 5 →