Synaptic Basis for Contrast-Dependent Shifts in Functional Identity in Mouse V1

被引:4
|
作者
Yunzab, Molis [1 ,2 ]
Choi, Veronica [3 ]
Meffin, Hamish [1 ,2 ]
Cloherty, Shaun L. [1 ,2 ,4 ]
Priebe, Nicholas J. [3 ]
Ibbotson, Michael R. [1 ,2 ]
机构
[1] Australian Coll Optometry, Natl Vis Res Inst, Carlton, Vic 3053, Australia
[2] Univ Melbourne, Dept Optometry & Vis Sci, Parkville, Vic 3010, Australia
[3] Univ Texas Austin, Ctr Learning & Memory, Austin, TX 78712 USA
[4] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
complex cell; in vivo whole-cell recording; phase sensitivity; primary visual cortex; visual system; RECEPTIVE-FIELD PROPERTIES; COMPLEX CELLS; PHASE SENSITIVITY; ORIENTATION SELECTIVITY; VISUAL-CORTEX; IN-VIVO; CORTICAL SIMPLE; STRIATE CORTEX; MACAQUE V1; NEURONS;
D O I
10.1523/ENEURO.0480-18.2019
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A central transformation that occurs within mammalian visual cortex is the change from linear, polarity-sensitive responses to nonlinear, polarity-insensitive responses. These neurons are classically labelled as either simple or complex, respectively, on the basis of their response linearity (Skottun et al., 1991). While the difference between cell classes is clear when the stimulus strength is high, reducing stimulus strength diminishes the differences between the cell types and causes some complex cells to respond as simple cells (Crowder et al., 2007; van Kleef et al., 2010; Hietanen et al., 2013). To understand the synaptic basis for this shift in behavior, we used in vivo whole-cell recordings while systematically shifting stimulus contrast. We find systematic shifts in the degree of complex cell responses in mouse primary visual cortex (V1) at the subthreshold level, demonstrating that synaptic inputs change in concert with the shifts in response linearity and that the change in response linearity is not simply due to the threshold nonlinearity. These shifts are consistent with a visual cortex model in which the recurrent amplification acts as a critical component in the generation of complex cell responses (Chance et al., 1999).
引用
收藏
页数:12
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