Synthesis of arylbromides from arenes and N-bromosuccinimide (NBS) in acetonitrile - A convenient method for aromatic bromination

被引：77
|
作者：
Zysman-Colman, Eli [1 ]
Arias, Karla [1 ]
Siegel, Jay S. [1 ]
机构：
[1] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland
来源：
CANADIAN JOURNAL OF CHEMISTRY | 2009年 / 87卷 / 02期
关键词：
arylbromides; electrophilic aromatic bromination; N-bromosuccinimide; REGIOSELECTIVE MONOBROMINATION; ACTIVATED AROMATICS; ELECTROPHILIC HALOGENATION; NUCLEAR; REAGENT; MILD; PHENOLS; HALOSUCCINIMIDES; HETEROAROMATICS; EFFICIENT;
D O I：
10.1139/V08-176
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Regioselective and chemoselective electrophilic bromination of a wide series of activated arenes using N-bromosuccinimide (NBS) in acetonitrile occurs readily. Environmentally friendly conditions, large substrate scope, and ease of synthesis enhance the utility of this method over other electrophilic bromination conditions.
引用
收藏
页码：440 / 447
页数：8
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