Synthesis of arylbromides from arenes and N-bromosuccinimide (NBS) in acetonitrile - A convenient method for aromatic bromination

被引：77

作者：

Zysman-Colman, Eli ^{[1
]}

Arias, Karla ^{[1
]}

Siegel, Jay S. ^{[1
]}

机构：

[1] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland

来源：

CANADIAN JOURNAL OF CHEMISTRY | 2009年 / 87卷 / 02期

关键词：

arylbromides; electrophilic aromatic bromination; N-bromosuccinimide; REGIOSELECTIVE MONOBROMINATION; ACTIVATED AROMATICS; ELECTROPHILIC HALOGENATION; NUCLEAR; REAGENT; MILD; PHENOLS; HALOSUCCINIMIDES; HETEROAROMATICS; EFFICIENT;

D O I：

10.1139/V08-176

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Regioselective and chemoselective electrophilic bromination of a wide series of activated arenes using N-bromosuccinimide (NBS) in acetonitrile occurs readily. Environmentally friendly conditions, large substrate scope, and ease of synthesis enhance the utility of this method over other electrophilic bromination conditions.

引用

页码：440 / 447

页数：8

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