First Report of OXA-181-Producing Escherichia coli in China and Characterization of the Isolate Using Whole-Genome Sequencing

被引:87
|
作者
Liu, Yanbin [1 ,2 ]
Feng, Yu [1 ,2 ]
Wu, Wenjing [1 ,2 ]
Xie, Yi [3 ]
Wang, Xiaohui [1 ,2 ]
Zhang, Xiaoxia [1 ,2 ]
Chen, Xinchuan [4 ]
Zong, Zhiyong [1 ,2 ,5 ]
机构
[1] Sichuan Univ, West China Hosp, Ctr Infect Dis, Chengdu 610064, Peoples R China
[2] State Key Lab Biotherapy, Div Infect Dis, Chengdu, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Lab Med, Lab Clin Microbiol, Chengdu 610064, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Haematol, Chengdu 610064, Peoples R China
[5] Sichuan Univ, West China Hosp, Dept Infect Control, Chengdu 610064, Peoples R China
关键词
KLEBSIELLA-PNEUMONIAE; BETA-LACTAMASE; ENTEROBACTERIACEAE; OXA-181; IDENTIFICATION; EMERGENCE; PLASMID; OXA-48; CARBAPENEMASES; BLA(NDM-1);
D O I
10.1128/AAC.00442-15
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We report the first OXA-181-producing strain in China. bla(OXA-181) was found in sequence type 410 (ST410) Escherichia coli strain WCHEC14828 from a Chinese patient without recent travel history. Genome sequencing and conjugation experiments were performed. bla(OXA-181) was carried on a 51-kb self-transmissible IncX3 plasmid and was linked with qnrS1, a quinolone resistance gene. bla(OXA-181) was introduced onto the IncX3 plasmid from a ColE2-type plasmid, and IncX3 plasmids have the potential to mediate the dissemination of bla(OXA-181).
引用
收藏
页码:5022 / 5025
页数:4
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