The effect of post-resistance exercise alcohol ingestion on lipopolysaccharide-stimulated cytokines

被引:9
|
作者
Levitt, Danielle E. [1 ,2 ]
Duplanty, Anthony A. [1 ,2 ]
Budnar, Ronald G., Jr. [1 ,2 ]
Luk, Hui-Ying [1 ,2 ]
Fernandez, Alexander [1 ]
Layman, Travis J. [1 ]
Fancher, Daniel L. [1 ]
Hill, David W. [1 ]
McFarlin, Brian K. [1 ,2 ]
Vingren, Jakob L. [1 ,2 ]
机构
[1] Univ N Texas, Appl Physiol Lab, Dept Kinesiol Hlth Promot & Recreat, 1155 Union Circle 310769, Denton, TX 76203 USA
[2] Univ N Texas, Dept Biol Sci, 1155 Union Circle 305220, Denton, TX 76203 USA
关键词
Resistance exercise; Alcohol; Lipopolysaccharide; Inflammation; ACUTE ETHANOL TREATMENT; NECROSIS-FACTOR-ALPHA; ECCENTRIC-EXERCISE; INFLAMMATORY RESPONSES; SKELETAL-MUSCLE; IMMUNE-SYSTEM; MONOCYTE; CONSUMPTION; ACTIVATION; EXPOSURE;
D O I
10.1007/s00421-015-3278-6
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Purpose To examine the effect of post-resistance exercise alcohol ingestion on lipopolysaccharide (LPS)-stimulated production of IFN gamma, TNF-alpha, IL-1 beta, IL-6, IL-8, and IL-10. Methods Recreationally resistance-trained men (n = 10, 25 +/- 3 year, 177 +/- 7 cm, 83.8 +/- 15.7 kg, 14.8 +/- 8.5 % body fat) and women (n = 8, 23 +/- 2 year, 161 +/- 3 cm, 59.5 +/- 6.0 kg, 26.5 +/- 3.0 % body fat) completed two identical heavy back squat sessions (6 x 10 at 80 % 1 repetition maximum) followed by ingestion of either an alcohol (ALC; 1.09 g ethanol . kg fat-free mass(-1)) or water (PLA) drink. Blood samples were collected before exercise (PRE), and at 3 h (3 h), and 5 h (5 h) after exercise, stimulated with LPS, and analyzed for IFN gamma, TNF-alpha, IL-1 beta, IL-6, IL-8, and IL-10 concentrations. Results There were no drink conditions by time effects for IFN gamma, TNF-alpha, IL-1 beta, or IL-10. Regardless of condition, resistance exercise induce an increase in IFN gamma, TNF-alpha, and IL-1 beta at 5 h compared to PRE but a decrease in IL-10 at 3 and 5 h compared to PRE. For ALC, IL-8 was reduced at 5 h compared to PLA. From PRE to 3 h, IL-6 was reduced for ALC but increased for PLA; resistance exercise induced an increase in IL-6 for both conditions at 5 h. Conclusions Heavy resistance exercise increased production of IFN gamma, TNF-alpha, IL-1 beta, and Il-6 and decreased production of IL-10. Alcohol ingestion after resistance exercise affected aspects of inflammatory capacity (IL-6 and IL-8 production). It appears that some of the effects previously observed for alcohol ingestion alone on the LPS-stimulated cytokine production were overwhelmed by the response to resistance exercise.
引用
收藏
页码:311 / 318
页数:8
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