Geraniol Restores Antibiotic Activities against Multidrug-Resistant Isolates from Gram-Negative Species

被引：195

作者：

Lorenzi, Vannina ^{[1
]}

Muselli, Alain ^{[4
]}

Bernardini, Antoine Francois ^{[4
]}

Berti, Liliane ^{[3
]}

Pages, Jean-Marie ^{[1
]}

Amaral, Leonard ^{[2
]}

Bolla, Jean-Michel ^{[1
]}

机构：

[1] Univ Aix Marseille 2, Fac Med, IFR88, UMR MD1, F-13385 Marseille 05, France

[2] Univ Nova Lisboa, Inst Hyg & Trop Med, Unit Mycobacteriol, P-1200 Lisbon, Portugal

[3] Univ Corse, Lab Biochim & Biol Mol Vegetal, CNRS, UMR 6134, F-20250 Corte, France

[4] Univ Corse, Equipe Chim Produits Nat, CNRS, UMR 6134, F-20250 Corte, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 05期

关键词：

EFFLUX PUMP INHIBITORS; ENTEROBACTER-AEROGENES;

D O I：

10.1128/AAC.00919-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Combinations of the two most active fractions of the essential oil with each other or with phenylalanine arginine beta-naphthylamide yield synergistic activity. Geraniol, a component of one fraction, significantly increased the efficacy of beta-lactams, quinolones, and chloramphenicol.

引用

页码：2209 / 2211

页数：3

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