Exploration of a β-cyclodextrin clicked chiral stationary phase in high-performance liquid chromatography

被引：16
|
作者：
Zhang, Shaopeng [1 ]
Wang, Huanhuan [1 ]
Tang, Jian [1 ]
Wang, Wei [2 ]
Tang, Weihua [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Minist Educ, Key Lab Soft Chem & Funct Mat, Nanjing 210094, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 211198, Jiangsu, Peoples R China
来源：
ANALYTICAL METHODS | 2014年 / 6卷 / 07期
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
SEPARATION; RECOGNITION; CHEMISTRY;
D O I：
10.1039/c3ay42193g
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The baseline enantioseparation of 19 racemic drugs including ondansetron, citalopram, galanthamine base, pregabalin, timolol, atenolol, tropicamide, ephedrine hydrochloride, flavanoids and aryl alcohols has been successfully achieved with a cyclodextrin clicked chiral stationary phase in high performance liquid chromatography. The best separation results were presented under optimized conditions. The effect of organic modifiers including methanol and acetonitrile on the enantioseparation of racemates was also studied. Chiral resolutions of 4.19 and 4.42 were achieved for citalopram and tropicamide, respectively.
引用
收藏
页码：2034 / 2037
页数：4
相关论文
共 50 条
  • [21] CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF AROMATIC CYCLIC DIPEPTIDES USING CYCLODEXTRIN STATIONARY PHASES
    FLORANCE, J
    KONTEATIS, Z
    JOURNAL OF CHROMATOGRAPHY, 1991, 543 (02): : 299 - 305
  • [22] "Click" immobilized perphenylcarbamated and permethylated cyclodextrin stationary phases for chiral high-performance liquid chromatography application
    Wang, Yong
    Young, David J.
    Tan, Timothy Thatt Yang
    Ng, Siu-Choon
    JOURNAL OF CHROMATOGRAPHY A, 2010, 1217 (31) : 5103 - 5108
  • [23] Effect of temperature on enantiomer separation of oxzepam and lorazepam by high-performance liquid chromatography on a β-cyclodextrin derivatized bonded chiral stationary phase
    He, H
    Liu, Y
    Sun, C
    Wang, XR
    Pham-Huy, C
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2004, 42 (02) : 62 - 66
  • [24] Synthesis of cationic β-cyclodextrin derivatives and their applications as chiral stationary phases for high-performance liquid chromatography and supercritical fluid chromatography
    Wang, Ren-Qi
    Ong, Teng-Teng
    Ng, Siu-Choon
    JOURNAL OF CHROMATOGRAPHY A, 2008, 1203 (02) : 185 - 192
  • [25] Preparation and Characterization of Cyclodextrin Polymer and Its High-Performance Liquid-Chromatography Stationary Phase
    Kwang-Pill Lee
    Seong-Ho Choi
    Eun-Nyoung Ryu
    Jae Jeong Ryoo
    Jung Hag Park
    Yongseong Kim
    Myung Ho Hyun
    Analytical Sciences, 2002, 18 : 31 - 34
  • [26] Preparation and characterization of cyclodextrin polymer and its high-performance liquid-chromatography stationary phase
    Lee, KP
    Choi, SH
    Ryu, EN
    Ryoo, JJ
    Park, JH
    Kim, Y
    Hyun, MH
    ANALYTICAL SCIENCES, 2002, 18 (01) : 31 - 34
  • [27] Engineering Cyclodextrin Clicked Chiral Stationary Phase for High-Efficiency Enantiomer Separation
    Jian Tang
    Shapopeng Zhang
    Yuzhou Lin
    Jie Zhou
    Limin Pang
    Xuemei Nie
    Baojing Zhou
    Weihua Tang
    Scientific Reports, 5
  • [28] Engineering Cyclodextrin Clicked Chiral Stationary Phase for High-Efficiency Enantiomer Separation
    Tang, Jian
    Zhang, Shapopeng
    Lin, Yuzhou
    Zhou, Jie
    Pang, Limin
    Nie, Xuemei
    Zhou, Baojing
    Tang, Weihua
    SCIENTIFIC REPORTS, 2015, 5
  • [29] Synthesis of novel chiral stationary phases for high-performance liquid chromatography
    Xu Lin Tan
    Chinese Chemical Letters, 2007, (04) : 461 - 464
  • [30] Synthesis of novel chiral stationary phases for high-performance liquid chromatography
    Tan, Xu Lin
    Hou, Shi Cong
    Bian, Qing Hua
    Wang, Min
    CHINESE CHEMICAL LETTERS, 2007, 18 (04) : 461 - 464
12345