Nutshell Extracts of Xanthoceras sorbifolia: A New Potential Source of Bioactive Phenolic Compounds as a Natural Antioxidant and Immunomodulator

被引:18
|
作者
Zhao, Li [1 ]
Li, Xing [1 ]
Ye, Ze-Qing [1 ]
Zhang, Fei [1 ]
Han, Juan-Juan [1 ]
Yang, Ting [1 ]
Wang, Zhe-Zhi [1 ]
Zhang, Yuan [1 ]
机构
[1] Shaanxi Normal Univ, Coll Life Sci, Natl Engn Lab Resource Dev Endangered Crude Drugs, Key Lab,Minist Educ Med Resources & Nat Pharmaceu, Xian 710119, Shaanxi, Peoples R China
关键词
Xanthoceras sorbifolia; nutshell extracts; phenolic constituents; antioxidant activities; experimental autoimmune encephalomyelitis; JAK/STAT pathway; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS LESIONS; NEURAL STEM-CELLS; SIGNALING PATHWAY; OXIDATIVE DAMAGE; NEUROINFLAMMATION; ACTIVATION; EXPRESSION; MECHANISM; BUNGE;
D O I
10.1021/acs.jafc.7b05590
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
The nutshell of Xanthoceras sorbifolia, a waste product in the production of edible oil, is rich in health-promoting phenolic acids. However, the individual constituents, bioactivities, and mechanism of action are largely unknown. In this study, 20 phenolic compounds were characterized in nutshell extract (NE) of X. sorbifolia by gas chromatography-mass spectrometry. Four established in vitro studies showed that NE has significant antioxidant potential. Results in vivo indicated that oral administration of NE effectively ameliorated clinical disease severity of experimental autoimmune encephalomyelitis (EAE) and reduced the neuroinflammation and the central nervous system (CNS) demyelination. The underlying mechanism of NE-induced effects involved decreased penetration of pathogenic immunocyte into the CNS, a reduced production of proinflammatory cytokines and factors, and suppressed differentiation of type 1 T helper and type 17 T helper cells through the Janus kinase/signal transducer and activator of transcription pathway. Taken together, our studies showed that X. sorbifolia nutshell, considered a waste material in the food industry, is a novel source of a natural antioxidant and immunomodulator.
引用
收藏
页码:3783 / 3792
页数:10
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