A novel isocoumarin with anti-influenza virus activity from Strobilanthes cusia

被引：29

作者：

Gu, Wei ^{[1
,2
]}

Wang, Wei ^{[4
]}

Li, Xiao-nian ^{[3
]}

Zhang, Yu ^{[3
]}

Wang, Li-ping ^{[1
,2
]}

Yuan, Chun-mao ^{[1
,2
]}

Huang, Lie-jun ^{[1
,2
]}

Hao, Xiao-jiang ^{[1
,2
,3
]}

机构：

[1] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Guizhou, Peoples R China

[2] Chinese Acad Sci, Guiyang 550002, Guizhou, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[4] Ocean Univ China, Sch Med & Pharm, Qingdao 266100, Shandong, Peoples R China

来源：

FITOTERAPIA | 2015年 / 107卷

关键词：

Strobilanthes cusia; Novel isocoumarin; Unprecedented skeleton; Anti-influenza virus activity; GLYCOSIDES;

D O I：

10.1016/j.fitote.2015.10.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Strobilanthes A (1), a novel isocoumarin with an unusual tetrahydro-4 H-pyran-4-one moiety fused isocoumarin core skeleton, together with a known compound (2) was isolated from Strobilanthes cusia. Its chemical structures were elucidated by 2D NMR spectroscopy, mass spectrometry and single-crystal X-ray diffraction analysis. The biosynthetic pathway of 1 could be supposed to be originally derived from 3-methylisocoumarin, a product of AA-MA pathway. Both of two compounds displayed anti-influenza virus activity in vitro. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：60 / 62

页数：3

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